Dilantin vs. Depakote

Common side effects of Dilantin include:

• headache,
• nausea,
• vomiting,
• constipation,
• dizziness,
• spinning sensation,
• drowsiness,
• slurred speech,
• loss of balance or coordination,
• swollen or tender gums,
• sleep problems (insomnia),
• nervousness,
• tremors, or
• rash.

Common side effects of Depakote include:

• drowsiness,
• weakness,
• nausea,
• vomiting,
• stomach upset,
• diarrhea,
• constipation,
• mood swings,
• changes in menstrual periods,
• enlarged breasts,
• weight changes,
• agitation,
• tremor (shaking),
• vision changes,
• unusual or unpleasant taste in your mouth, and
• hair loss.

Antiepileptic drugs (AEDs), including Depakote, increase the risk of suicidal thoughts or behavior in patients taking these drugs for any indication. Tell your doctor if you have new or worsening depression, suicidal thoughts or behavior, and/or any unusual changes in mood or behavior.

Dilantin (phenytoin) is an anti-epileptic drug, also called an anticonvulsant, used to control seizures.

Depakote (divalproex sodium) is a stable coordination compound comprised of sodium valproate and valproic acid used to treat manic episodes associated with bipolar disorder, epilepsy, and migraine headaches. Generic Depakote (termed divalproex sodium) is available under several other names.

Dilantin may interact with stomach acid reducers, sedatives, antidepressants, estrogen hormone replacement, phenothiazines, disulfiram, methylphenidate, sulfa drugs, carbamazepine, sucralfate, molindone, phenobarbital, valproic acid, divalproex sodium, steroids, antibiotics, digoxin, furosemide, or theophylline. Tell your doctor all medications you use.

Depakote may interact with ritonavir, phenytoin, carbamazepine, phenobarbital, primidone, aspirin, carbapenem antibiotics, felbamate, rifampin, amitriptyline, nortriptyline, carbamazepine, clonazepam, diazepam, ethosuximide, lamotrigine, tolbutamide, warfarin, zidovudine, lorazepam, and topiramate.

Patients may be started on one 100-mg Dilantin Extended Oral Capsule three times daily. For most adults, the maintenance dosage is one capsule three to four times a day. The initial pediatric dose is 5 mg/kg/day in two or three equally divided doses, with dosage individualized to a maximum of 300 mg daily. Daily maintenance dosage is usually 4 to 8 mg/kg.

The recommended initial dose of Depakote to treat mania is 750 mg daily in divided doses. The dose of Depakote to treat epilepsy as monotherapy should be initiated at 10 to 15 mg/kg/day. The recommended starting dose of Depakote to treat migraines is 250 mg twice daily.