Aklief vs. Amnesteem

• Are Aklief and Amnesteem the Same Thing?
• What Are Possible Side Effects of Aklief?
• What Are Possible Side Effects of Amnesteem?
• What Is Aklief?
• What Is Amnesteem?
• What Drugs Interact with Aklief?
• What Drugs Interact with Amnesteem?
• How Should Aklief Be Taken?
• How Should Amnesteem Be Taken?

Aklief (trifarotene) Cream and Amnesteem (isotretinoin capsules) are retinoids used to treat acne vulgaris.

Amnesteem is used to treat severe recalcitrant nodular acne.

Aklief Cream is a topical preparation and Amnesteem is taken orally.

Side effects of Aklief Cream that are different from Amnesteem include application site reactions (such as irritation, itching, pain, redness, dryness, stinging/burning, discoloration, rash, swelling, and lesions), sunburn, acne, and allergic dermatitis.

Side effects of Amnesteem that are different from Aklief Cream include dry skin, chapped lips, dry eyes, and dry nose that may lead to nosebleeds.

Aklief Cream may interact with other drugs.

Amnesteem may interact with vitamin A, tetracycline antibiotics, hormonal contraceptives, St. John's wort, phenytoin, and corticosteroids.

Common side effects of Aklief include:

• application site reactions such as:
• irritation,
• itching,
• pain,
• redness,
• dryness,
• stinging/burning,
• discoloration,
• rash,
• swelling, and
• lesions
• sunburn,
• acne, and
• allergic dermatitis

Common side effects of Amnesteem include:

• dry skin,
• chapped lips,
• dry eyes, and
• dry nose that may lead to nosebleeds.

Tell your doctor if you have serious side effects of Amnesteem including:

• increased brain pressure (severe headache, blurred vision, dizziness, nausea, vomiting, seizures, or stroke);
• a rash with a fever,
• blisters on legs, arms or face and/or sores in your mouth, throat, nose, eyes, or if your skin begins to peel;
• severe stomach, chest, or bowel pain;
• trouble swallowing or painful swallowing,
• new or worsening heartburn,
• diarrhea,
• rectal bleeding,
• yellowing of your skin or eyes,
• dark urine,
• back pain,
• joint pain,
• broken bones,
• hearing problems,
• vision problems, and
• blood sugar problems.

Aklief (trifarotene) Cream is a retinoid indicated for the topical treatment of acne vulgaris in patients 9 years of age and older.

Amnesteem (isotretinoin capsules) is a retinoid indicated for the treatment of severe recalcitrant nodular acne.

Aklief may interact with other drugs. Tell your doctor all medications and supplements you use.

Amnesteem may interact with steroids or tetracycline antibiotics.

Amnesteem may also interact with vitamin A, hormonal contraceptives, St. John's wort, and phenytoin.

The dose of Aklief Cream is a thin layer applied to the affected areas of the face and/or trunk once a day, in the evening, on clean and dry skin.

The recommended dosage range for Amnesteem is 0.5 to 1 mg/kg/day given in two divided doses with food for 15 to 20 weeks.