Aciphex vs. Prilosec

• Are Aciphex and Prilosec the Same Thing?
• What Are Possible Side Effects of Aciphex?
• What Are Possible Side Effects of Prilosec?
• What Is Aciphex?
• What Is Prilosec?
• What Drugs Interact with Aciphex?
• What Drugs Interact with Prilosec?
• How Should Aciphex Be Taken?
• How Should Prilosec Be Taken?

Aciphex (rabeprazole sodium) and Prilosec (omeprazole) are proton pump inhibitors (PPIs) used to reduce stomach acid to treat gastroesophageal reflux disease (GERD), and duodenal ulcers.

Aciphex is also used in combination with antibiotics to treat Helicobacter pylori (H. pylori) bacterial infections in the stomach.

Prilosec is available over-the-counter (OTC) and as a generic.

Side effects of Aciphex and Prilosec that are similar include diarrhea, gas, sore throat, and headache.

Side effects of Aciphex that are different from Prilosec include rash or itching, upset stomach, insomnia, and nervousness.

Side effects of Prilosec that are different from Aciphex include nausea, vomiting, stomach pain, constipation, fever, and cold symptoms (stuffy nose, sneezing).

Both Aciphex and Prilosec may interact with methotrexate, digoxin, ketoconazole, and blood thinners.

Aciphex may also interact with atazanavir, diuretics (water pills), and cyclosporine.

Prilosec may also interact with clopidogrel, St. John's wort, antibiotics, diazepam, and phenytoin.

Common side effects of Aciphex include:

• rash or itching,
• upset stomach,
• diarrhea,
• gas,
• sore throat,
• headache,
• insomnia, or
• nervousness.

Serious side effects of Aciphex include:

• hepatitis,
• abnormal brain function or structure (encephalopathy),
• dizziness,
• swelling,
• joint pain, and
• muscle pains.

Common side effects of Prilosec include:

• headache,
• nausea,
• vomiting,
• diarrhea,
• stomach pain,
• gas,
• constipation,
• fever, or
• cold symptoms (stuffy nose, sneezing, and sore throat).

Aciphex (rabeprazole sodium) is a proton pump inhibitor (PPI) to reduce stomach acid and is used for the treatment of gastroesophageal reflux disease (GERD), duodenal ulcers, and used in combination with antibiotics to treat Helicobacter pylori (H. pylori) bacterial infections in the stomach.

Prilosec (omeprazole) is a proton pump inhibitor (PPI) used for the treatment of conditions such as ulcers, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome, which are all caused by stomach acid.

Aciphex may interact with atazanavir, blood thinners, digoxin, diuretics (water pills), ketoconazole, or methotrexate.

Aciphex may also interact with cyclosporine.

Prilosec may interact with digoxin, diuretics (water pills), blood thinners, antifungal medications such as ketoconazole, antibiotics such as ampicillin, iron, or methotrexate, and HIV or AIDS medications such as atazanavir and nelfinavir.

Prilosec may also interact with bosentan, cilostazol, clopidogrel, cyclosporine, diazepam, disulfiram, St. John's wort, tacrolimus, or seizure medications.

• Take Aciphex exactly as prescribed. Your doctor will prescribe the dose that is right for you and your medical condition. Do not change your dose or stop taking Aciphex unless you talk to your doctor. Take Aciphex for as long as it is prescribed even if you feel better.
• Aciphex is usually taken 1 time each day. Your doctor will tell you the time of day to take Aciphex, based on your medical condition.
• Aciphex can be taken with or without food. Your doctor will tell you whether to take this medicine with or without food based on your medical condition.
• Swallow each Aciphex tablet whole. Do not chew, crush, or split Aciphex tablets. Tell your doctor if you cannot swallow tablets whole.
• If you miss a dose of Aciphex, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your normal schedule. Do not take 2 doses at the same time.
• If you take too much Aciphex, call your doctor or your poison control center at 1-800-222-1222 right away, or go to the nearest hospital emergency room.
• Your doctor may prescribe antibiotic medicines with Aciphex to help treat a stomach infection and heal stomach (duodenal) ulcers that are caused by bacteria called H. pylori. Make sure you read the patient information that comes with an antibiotic before you start taking it.

The recommended adult oral dose of Prilosec ranges from 20 mg to 60 mg once daily, depending on the condition being treated. For maximal efficacy, Prilosec tablets should be taken before meals, swallowed whole and should not be crushed, chewed or opened.