Aczone (Dapzone) vs. Cubicin

Dapsone and Cubicin (daptomycin) are antibiotics used to treat skin conditions.

Dapsone is used in the treatment of dermatitis herpetiformis (a skin condition) and leprosy (Hansen's disease).

Cubicin is used to treat bacterial infections of the skin and underlying tissues.

A brand name for dapsone is Aczone.

Side effects of dapsone and Cubicin that are similar include nausea, vomiting, dizziness, headache, or sleep problems (insomnia).

Side effects of dapsone that are different from Cubicin include loss of appetite, blurred vision, ringing in the ears, or increased sensitivity of the skin to sunlight.

Side effects of Cubicin that are different from dapsone include constipation, diarrhea, swelling, back pain, pain in your arms or legs, anxiety, itching or skin rash, increased sweating, or injection site reactions (pain, discomfort, irritation, redness, or swelling).

Dapsone may interact with other drugs.

Cubicin may interact with blood thinners, tobramycin, or “statin” cholesterol-lowering medicines.

Side effects of Aczone include:

• skin dryness,
• redness,
• oiliness, and
• peeling.

Common side effects of Cubicin include:

• nausea,
• vomiting,
• constipation,
• diarrhea,
• headache,
• swelling,
• back pain,
• pain in your arms or legs,
• dizziness,
• trouble sleeping (insomnia),
• anxiety,
• itching or skin rash,
• increased sweating, or
• injection site reactions (pain, discomfort, irritation, redness, or swelling).

Tell your doctor if you have serious side effects of Cubicin including:

• muscle pain/cramps/weakness,
• numbness or tingling of hands or feet,
• unusual tiredness or weakness,
• changes in amount of urine,
• chest pain,
• swelling,
• shakiness,
• increased thirst,
• blurred vision,
• unusual bleeding or bruising,
• irregular heartbeat,
• yellowing of the skin or eyes,
• dark urine,
• cough,
• difficult or painful breathing, or
• new or unexplained fever.

Aczone (dapsone) Gel, 5% is a sulfone drug indicated for the topical treatment of acne vulgaris. Aczone Gel 5% is available in generic form.

Cubicin (daptomycin) is an antibiotic used to treat bacterial infections of the skin and underlying tissues.

Aczone Gel 5% may interact with other topical medications, harsh or abrasive soaps, or cosmetics on the affected area. Tell your doctor all medications, supplements, and skin care products you use. Tell your doctor if you are pregnant or plan to become pregnant before using Aczone Gel 5%; it is unknown if it will harm a fetus. Aczone Gel 5% passes into breast milk and may affect a nursing baby. Consult your doctor before breastfeeding.

Cubicin may interact with blood thinners, tobramycin, or cholesterol-lowering medicines. Tell your doctor all medications you are taking. Cubicin should be used only when prescribed during pregnancy. It is not known whether this drug passes into breast milk. Consult your doctor before breastfeeding.

For topical use only. Not for oral, ophthalmic, or intravaginal use. After the skin is gently washed and patted dry, apply approximately a pea-sized amount of Aczone Gel 5%, in a thin layer to the acne affected areas twice daily. Rub in Aczone Gel 5% gently and completely. Wash hands after application of Aczone Gel 5%.

The dose and duration of treatment with Cubicin depends upon the condition being treated. It is administered intravenously either by injection over a two (2) minute period or by infusion over a thirty (30) minute period.