Educational Content: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider for diagnosis and treatment.
Definition of Hyperchloremia
Medically reviewed by Min Clinic Staff | Updated: January 2026
Hyperchloremia: Elevated blood levels of chloride.
Chloride is the major anion found in the fluid outside of cells and in blood. An anion is the negatively charged part of certain substances such as table salt (NaCl) when dissolved in liquid. Sea water has almost the same concentration of chloride ion as human fluids.
The balance of chloride ion (Cl-) is closely regulated by the body. Significant increases or decreases in chloride can have deleterious or even fatal consequences.
Increased chloride (hyperchloremia): Elevations in chloride may be seen in diarrhea, certain kidney diseases, and sometimes in overactivity of the parathyroid glands.