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Definition of Protein kinase A
Medically reviewed by Min Clinic Staff | Updated: January 2026
Protein kinase A: An enzyme system that is activated by cyclic adenosine monophosphate (cAMP) and that catalyzes the activity of intracellular proteins. There are two isozymes of protein kinase A, type I and type II. Also known as cAMP-dependent protein kinase and cyclic AMP-dependent protein kinase.