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Definition of Secondary amenorrhea

Medically reviewed by Min Clinic Staff | Updated: January 2026

Secondary amenorrhea: The cessation of menstruation for abnormal reasons. Causes include anorexia nervosa, disease of the female reproductive tract, and overexercise. Secondary amenorrhea can also be caused by certain medications, notably the birth control medication medroxyprogesterone (brand name: Depo-Provera); in this case, amenorrhea is an expected effect.