Amikacin Sulfate Injection
- Generic Name: amikacin sulfate
- Brand Name: Amikacin Sulfate Injection
Amikacin Sulfate Injection (amikacin sulfate) side effects drug center
Amikacin Sulfate Injection Side Effects Center
What Is Amikacin Sulfate?
Amikacin Sulfate Injection is an aminoglycoside antibiotic indicated in the short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria, including Pseudomonas species, Escherichia coli, species of indole-positive and indole-negative Proteus, Providencia species, Klebsiella-Enterobacter-Serratia species, and Acinetobacter (Mima-Herellea) species. Amikacin Sulfate Injection is available in generic form.
What Are Side Effects of Amikacin Sulfate?
Common side effects of Amikacin Sulfate Injection include:
- diarrhea,
- hearing loss,
- spinning sensation (vertigo),
- numbness,
- skin tingling,
- muscle twitching and convulsions,
- dizziness,
- ringing or roaring in the ears,
- allergic reactions,
- Clostridium difficile associated diarrhea (CDAD),
- skin rash,
- drug fever,
- headache,
- numbness and tingling,
- tremor,
- nausea,
- vomiting,
- increase in white blood cells (eosinophilia),
- joint pain,
- anemia,
- low blood pressure, and
- low blood magnesium.
Dosage for Amikacin Sulfate
The recommended dosage of Amikacin Sulfate Injection for adults, children and older infants with normal renal function is 15 mg/kg/day divided into 2 or 3 equal doses administered at equally-divided intervals, i.e., 7.5 mg/kg q12h or 5 mg/kg q8h. The usual duration of treatment is 7 to 10 days.
What Drugs, Substances, or Supplements Interact with Amikacin Sulfate?
Amikacin Sulfate Injection may interact with other neurotoxic or nephrotoxic products (particularly bacitracin, cisplatin, amphotericin B, cephaloridine, paromomycin, viomycin, polymyxin B, colistin, vancomycin, or other aminoglycosides, and potent diuretics (ethacrynic acid, or furosemide). Tell your doctor all medications and supplements you use.
Amikacin Sulfate During Pregnancy and Breastfeeding
Amikacin Sulfate Injection is not recommended for use during pregnancy. It is unknown if Amikacin Sulfate passes into breast milk. Because of the potential for adverse effects in a nursing infant, breastfeeding while using Amikacin Sulfate is not recommended.
Additional Information
Our Amikacin Sulfate Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
Amikacin Sulfate Injection Consumer Information
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- hearing loss, or a roaring sound in your ears;
- severe or ongoing dizziness;
- kidney problems--little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath;
- weak or shallow breathing;
- numbness or tingly feeling;
- muscle twitching or seizure (convulsions); or
- severe stomach pain, diarrhea that is watery or bloody.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Amikacin Sulfate Injection (amikacin sulfate)
Amikacin Sulfate Injection Professional Information
SIDE EFFECTS
All aminoglycosides have the potential to induce auditory, vestibular, and renal toxicity and neuromuscular blockade (see WARNINGS box). They occur more frequently in patients with present or past history of renal impairment, of treatment with other ototoxic or nephrotoxic drugs, and in patients treated for longer periods and/or with higher doses than recommended.
Neurotoxicity-Ototoxicity
Toxic effects on the eighth cranial nerve can result in hearing loss, loss of balance, or both. Amikacin primarily affects auditory function. Cochlear damage includes high frequency deafness and usually occurs before clinical hearing loss can be detected.
Neurotoxicity-Neuromuscular Blockade
Acute muscular paralysis and apnea can occur following treatment with aminoglycoside drugs.
Nephrotoxicity
Elevation of serum creatinine, albuminuria, presence of red and white cells, casts, azotemia, and oliguria have been reported. Renal function changes are usually reversible when the drug is discontinued. As would be expected with any aminoglycoside, reports of toxic nephropathy and acute renal failure have been received during postmarketing surveillance.
Other
In addition to those described above, other adverse reactions which have been reported on rare occasions are skin rash, drug fever, headache, paresthesia, tremor, nausea and vomiting, eosinophilia, arthralgia, anemia, hypotension and hypomagnesemia. Macular infarction sometimes leading to permanent loss of vision has been reported following intravitreous administration (injection into the eye) of amikacin.
Read the entire FDA prescribing information for Amikacin Sulfate Injection (amikacin sulfate)
© Amikacin Sulfate Injection Patient Information is supplied by Cerner Multum, Inc. and Amikacin Sulfate Injection Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.