Dalgan

Dalgan - General Information

Dalgan is a partial opiate drug and is used for pain management. Dalgan is a very effective alternative to fentanyl when administered during outpatient laparoscopy, although is associated with an increased incidence of postoperative nausea.

Pharmacology of Dalgan

Dalgan is a parenteral narcotic analgesic possessing both agonist and antagonist activity. It is similar to morphine with respect to analgesic potency and onset and duration of action. The narcotic antagonist activity is greater than that of pentazocine.

Dalgan for patients

Dalgan Interactions

Additive depressant effect when used with general anesthetics, sedatives, antianxiety drugs, hypnotics, alcohol, and other opiate analgesics.

Dalgan Contraindications

Lactation. Individuals dependent on narcotics. SC administration.

Additional information about Dalgan

Dalgan Indication: Indicated in the treatment of moderate to severe pain.
Mechanism Of Action: Dalgan is a opioid receptor antagonist. It binds with stereospecific receptors at many sites within the central nervous system (CNS) to alter processes affecting both the perception of pain and the emotional response to pain. At least 2 of these types of receptors (mu and kappa) mediate analgesia. Mu receptors are widely distributed throughout the CNS, especially in the limbic system (frontal cortex, temporal cortex, amygdala, and hippocampus), thalamus, striatum, hypothalamus, and midbrain as well as laminae I, II, IV, and V of the dorsal horn in the spinal cord. Kappa receptors are localized primarily in the spinal cord and in the cerebral cortex.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Dezocine
Synonyms: Dezocina [INN-Spanish]; Dezocinum [INN-Latin]
Drug Category: Analgesics, Opioid
Drug Type: Small Molecule; Approved

Other Brand Names containing Dezocine: Dalgan;
Absorption: Rapid and complete following intramuscular administration.
Toxicity (Overdose): Symptoms of overdose include cold and clammy skin, confusion, nervousness, or severe restlessness, convulsions (seizures), severe dizziness, severe drowsiness, low blood pressure, pinpoint pupils of eyes, slow heartbeat, slow or troubled breathing and severe weakness.
Protein Binding: Not Available
Biotransformation: Hepatic, via conjugation (glucuronidation).
Half Life: Elimination half-life following intramuscular administration averages 2.2 hours. Elimination half-life following a 5mg intravenous dose averages 1.7 to 2.6 hours (range 0.6 to 4.4 hours) while a 10mg dose averages 2.4 to 2.6 hours (range 1.2 to 7.4 hours). In patients with hepatic cirrhosis, the half-life is increased by 30 to 50%.
Dosage Forms of Dalgan: Not Available
Chemical IUPAC Name: Not Available
Chemical Formula: C16H23NO
Dezocine on Wikipedia: Not Available
Organisms Affected: Humans and other mammals