Yo-yo-ing

Yo-yo-ing

Yo-yo-ing is a form of dyskinesia experienced by patients with idiopathic Parkinson’s disease who have been treated for several years with levodopa preparations, in which there are sudden and unpredictable swings between hypokinesia/akinesia ("off " state; freezing) and severe hyperkinesia ("on" state), sometimes known as the "on-off phenomenon." Yo-yo-ing is difficult to treat: approaches include dose fractionation, improved drug absorption, or use of dopaminergic agonists with concurrent reduction in levodopa dosage.

Cross References

Akinesia; Dyskinesia; Hypokinesia