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Zefazone: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Zefazone - General Information

A semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and gram-negative microorganisms. It has a high rate of efficacy in many types of infection and to date no severe side effects have been noted. [PubChem]

 

Pharmacology of Zefazone

Zefazone is a second-generation cephalosporin. The cephalosporins are bactericidal drugs with both gram-positive and gram-negative activity. They inhibit bacterial cell wall synthesis in a way similar to the penicillins. Zefazone is more active than 1st-generation cephalosporins against indole-positive Proteus, Serratia, anaerobic gram-negative bacilli (including B. fragilis), and some E. coli, Klebsiella, and P. mirabilis, but is less active than cefoxitin or cefotetan against most gram-negative bacilli.

 

Additional information about Zefazone

Zefazone Indication: For the treatment of infections caused by susceptible organisms. Mechanism Of Action: The bactericidal activity of cefmetazole results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Cefmetazole Synonyms: Cefmetazole sodium; Cefmetazolo [INN-Spanish]; Cefmetazolum [INN-Latin] Drug Category: Anti-Bacterial Agents Drug Type: Small Molecule; Approved Other Brand Names containing Cefmetazole: Zefazone; Absorption: Bioavailability is approximately 100% following intramuscular injection. Toxicity (Overdose): Oral LD50 in rats is 3,204 mg/kg. With other b-lactam antibiotics, adverse effects following overdosage have included nausea, vomiting, epigastric distress, diarrhea, and convulsions. Protein Binding: Not Available Biotransformation: No appreciable metabolism. Half Life: 1.50 ±0.14 hours Dosage Forms of Zefazone: Powder, for solution Intramuscular Chemical IUPAC Name: (6R,7S)-7-[[2-(cyanomethylsulfanyl)acetyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical Formula: C15H17N7O5S3 Cefmetazole on Wikipedia: https://en.wikipedia.org/wiki/Cefmetazole Organisms Affected: Enteric bacteria and other eubacteria