Zefazone
Zefazone - General Information
A semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and gram-negative microorganisms. It has a high rate of efficacy in many types of infection and to date no severe side effects have been noted. [PubChem]
Pharmacology of Zefazone
Zefazone is a second-generation cephalosporin. The cephalosporins are bactericidal drugs with both gram-positive and gram-negative activity. They inhibit bacterial cell wall synthesis in a way similar to the penicillins. Zefazone is more active than 1st-generation cephalosporins against indole-positive Proteus, Serratia, anaerobic gram-negative bacilli (including B. fragilis), and some E. coli, Klebsiella, and P. mirabilis, but is less active than cefoxitin or cefotetan against most gram-negative bacilli.
Additional information about Zefazone
Zefazone Indication: For the treatment of infections caused by susceptible organisms.
Mechanism Of Action: The bactericidal activity of cefmetazole results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Cefmetazole
Synonyms: Cefmetazole sodium; Cefmetazolo [INN-Spanish]; Cefmetazolum [INN-Latin]
Drug Category: Anti-Bacterial Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Cefmetazole: Zefazone;
Absorption: Bioavailability is approximately 100% following intramuscular injection.
Toxicity (Overdose): Oral LD50 in rats is 3,204 mg/kg. With other b-lactam antibiotics, adverse effects following overdosage have included nausea, vomiting, epigastric distress, diarrhea, and convulsions.
Protein Binding: Not Available
Biotransformation: No appreciable metabolism.
Half Life: 1.50 ±0.14 hours
Dosage Forms of Zefazone: Powder, for solution Intramuscular
Chemical IUPAC Name: (6R,7S)-7-[[2-(cyanomethylsulfanyl)acetyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Chemical Formula: C15H17N7O5S3
Cefmetazole on Wikipedia: https://en.wikipedia.org/wiki/Cefmetazole
Organisms Affected: Enteric bacteria and other eubacteria
