Yutopar
Yutopar - General Information
Adrenergic beta-agonist used to control premature labor. [PubChem]
Pharmacology of Yutopar
Beta-2 adrenergic receptors are located at sympathetic neuroeffector junctions of many organs, including uterus. Yutopar is beta-2 adrenergic agonist. It stimulates beta-2 adrenergic receptor, increases cAMP level and decreases intracellular calcium concentration. The decrease of calcium concentration leads to a relaxation of uterine smooth muscle.
Yutopar for patients
Patient Information:
Ritodrine is used to stop premature labor. Contact your doctor immediately if
the contractions start again or water breaks.
Do not change the dose of Ritodrine of dosing schedule. Do not start any new
medication (include the prescription and non-prescription medication) without
checking with your doctor.
Yutopar Interactions
Ritodrine may interact with the folloing medications:
-Anesthetics: may potentiate the hypotensive effects
-Diazoxide, parenteral
-Magnesium sulfate
-Meperidine
-sympathomimetic amines: may be additive
-Beta-adrenergic antagonists: inhibit Ritodrine
-Corticosteroids: may cause pulmonary edema
Yutopar Contraindications
Ritodrine should not be giving to patient under the following medical conditions
(except special situations):
-pregnancy less than 20 weeks
-antepartum hemorrhage which demands immediate delivery
-eclampsia and severe preeclampsia
-intra-uterine fetal death
-chorioamnionitis
-maternal cardiac disease
-pulmonary hypertension
-maternal hyperthyroidism
-uncontrolled maternal diabetes mellitus
-pre-existing maternal medical conditions:
*hypovolemia
*cardiac arrhythmias associated with tachycardia or digitalis intoxication
*uncontrolled hypertension
*pheochromocytoma
*bronchial asthma already treated by betamimetics and/or steroids
*known hypersensitivity to any component of the product
*parenteral ritodrine: history of hypersensitivity to sulfite
*asthma patients may react with bronchospasm and anaphylactic shock.
Additional information about Yutopar
Yutopar Indication: For the treatment and prophylaxis of premature labour
Mechanism Of Action: Yutopar is beta-2 adrenergic agonist. It binds to beta-2 adrenergic receptors on outer membrane of myometrial cell, activates adenyl cyclase to increase the level of cAMP which decreases intracellular calcium and leads to a decrease of uterine contractions.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Ritodrine
Synonyms: Ritodrina [Inn-Spanish]; Ritodrine Hcl; Ritodrine Hydrochloride; Ritodrinium [Inn-Latin]
Drug Category: Adrenergic beta-Agonists; Tocolytic Agents; Sympathomimetic
Drug Type: Small Molecule; Approved
Other Brand Names containing Ritodrine: Yutopar; Yutopar S.R;
Absorption: Not Available
Toxicity (Overdose): LD50=64mg/kg (mice, IV); LD50=540 mg/kg (mice, oral); LD50=85 mg/kg (rat, IV)
Protein Binding: ~56%
Biotransformation: Hepatic, by both the mother and fetus
Half Life: 1.7-2.6 hours
Dosage Forms of Yutopar: Not Available
Chemical IUPAC Name: 4-[(1R,2S)-1-hydroxy-2-[2-(4-hydroxyphenyl)ethylamino]propyl]phenol
Chemical Formula: C17H21NO3
Ritodrine on Wikipedia: https://en.wikipedia.org/wiki/Ritodrine
Organisms Affected: Humans and other mammals