Vontil

Vontil - General Information

Vontil is a potent neuroleptic with antipsychotic properties. Vontil has a marked cataleptic and antiapomorphine activity associated with relatively slight sedative, hypothermic and spasmolytic effects. It is virtually without antiserotonin and hypotensive action and has no antihistaminic property. It is used for the treatment of all types of acute and chronic schizophrenia, including those which did not respond to the usual neuroleptics; manic syndromes.
Overdosage may result in severe extrapyramidal symptoms with dysphagia, marked sialorrhea, persistent and rapidly increasing hyperthermia, pulmonary syndrome, state of shock with pallor and profuse sweating, which may be followed by collapse and coma. LD50 in mice is 70 mg/kg I.V., 120 mg/kg I.P., 500 mg/kg S.C. and 830 mg/kg P.O.

Pharmacology of Vontil

Vontil is a potent neuroleptic with antipsychotic properties. Vontil has a marked cataleptic and antiapomorphine activity associated with relatively slight sedative, hypothermic and spasmolytic effects. It is virtually without antiserotonin and hypotensive action and has no antihistaminic property.

Additional information about Vontil

Vontil Indication: For the treatment of all types of acute and chronic schizophrenia, including those which did not respond to the usual neuroleptics; manic syndromes.
Mechanism Of Action: Not Available
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Thioproperazine
Synonyms: Tioproferazina [inn-spanish]; Thiproperazine; Thioproperazinum [inn-latin]; Thioproperazin; Thioperazine
Drug Category: Antipsychotic Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Thioproperazine: Vontil; Sulfenazin; Megeptil; Mazeptyl; Mazeptil; Majeptyl; Cephalmin;
Absorption: Not Available
Toxicity (Overdose): Overdosage may result in severe extrapyramidal symptoms with dysphagia, marked sialorrhea, persistent and rapidly increasing hyperthermia, pulmonary syndrome, state of shock with pallor and profuse sweating, which may be followed by collapse and coma. LD50 in mice is 70 mg/kg I.V., 120 mg/kg I.P., 500 mg/kg S.C. and 830 mg/kg P.O.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Vontil: Tablet Oral
Chemical IUPAC Name: N,N-dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine-2-sulfonamide
Chemical Formula: C22H30N4O2S2
Thioproperazine on Wikipedia: Not Available
Organisms Affected: Humans and other mammals