Vexol
Vexol - General Information
Vexol is a glucocorticoid steroid used to treat inflammation in the eye. It is marketed as a 1% eye drop solution under the trade name Vexol
Pharmacology of Vexol
Vexol is a glucocorticoid corticosteroid for systemic use. Corticosteroids suppress the inflammatory response to a variety of inciting agents of a mechanical, chemical, or immunological nature. They inhibit edema, cellular infiltration, capillary dilatation, fibroblastic proliferation, deposition of collagen and scar formation associated with inflammation.
Vexol for patients
Do not touch dropper tip to any surface, as this may contaminate the suspension.
Vexol Interactions
Vexol Contraindications
VEXOL® 1% is contraindicated in epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, varicella, and most other viral diseases of the cornea and conjunctiva; mycobacterial infection of the eye; fungal diseases of the eye; acute purulent untreated infections which, like other diseases caused by microorganisms, may be masked or enhanced by the presence of the steroid; and in those persons with hypersensitivity to any component of the formulation.
Additional information about Vexol
Vexol Indication: For the treatment of postoperative inflammation following ocular surgery and in the treatment of anterior uveitis.
Mechanism Of Action: Betamethasone is a glucocorticoid receptor agonist. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition of arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Rimexolone
Synonyms: Not Available
Drug Category: Anti-inflammatory Agents; Corticosteroids
Drug Type: Small Molecule; Approved
Other Brand Names containing Rimexolone: Vexol;
Absorption: Systemically absorbed.
Toxicity (Overdose): Symptoms of overdose include retinal toxicity, glaucoma, and subcapsular cataract.
Protein Binding: Not Available
Biotransformation: Undergoes extensive metabolism. Following intravenous administration of radiolabeled rimexolone in rats, more than 80% of the dose was excreted in the feces as rimexolone and metabolites. Metabolites have been shown to be either less active than rimexolone or inactive in human glucocorticoid receptor binding assays.
Half Life: The serum half-life of rimexolone could not be reliably estimated due to the large number of samples below the quantitation limit of the assay (80 pg/mL). However, based on the time required to reach steady-state, the half-life appears to be short (1-2 hours).
Dosage Forms of Vexol: Suspension Ophthalmic
Chemical IUPAC Name: (10R,11S,13S,16R,17S)-11-hydroxy-10,13,16,17-tetramethyl-17-propanoyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
Chemical Formula: C24H34O3
Rimexolone on Wikipedia: https://en.wikipedia.org/wiki/Rimexolone
Organisms Affected: Humans and other mammals
