Veramina

Veramina - General Information

An antibiotic produced by Streptomyces fradiae. [PubChem]

Pharmacology of Veramina

Veramina is a broad spectrum antibiotic that concentrates in kidney and bladder and is used to treat uncomplicated urinary tract infections. Veramina also reduces nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents.

Veramina for patients

Patients should be informed:

• That MONUROL (fosfomycin tromethamine) can be taken with or without food.
• That their symptoms should improve in two to three days after taking MONUROL; if not improved, the patient should contact her health care provider.

Veramina Interactions

Metoclopramide: When coadministered with MONUROL, metoclopramide, a drug which increases gastrointestinal motility, lowers the serum concentration and urinary excretion of fosfomycin. Other drugs that increase gastrointestinal motility may produce similar effects.

Cimetidine: Cimetidine does not affect the pharmacokinetics of fosfomycin when coadministered with MONUROL.

Veramina Contraindications

MONUROL is contraindicated in patients with known hypersensitivity to the drug.

Additional information about Veramina

Veramina Indication: For the treatment of uncomplicated urinary tract infections (acute cystitis) in women due to susceptible strains of Escherichia coli and Enterococcus faecalis.
Mechanism Of Action: Veramina is a phosphoenolpyruvate analogue produced by Streptomyces that irreversibly inhibits enolpyruvate transferase (MurA), which prevents the formation of N-acetylmuramic acid, an essential element of the peptidoglycan cell wall.
Drug Interactions: Not Available
Food Interactions: Take without regard to meals.
Food decreases Cmax slightly.
Generic Name: Fosfomycin
Synonyms: Fosfomycin disodium salt; Fosfomycin sodium; Fosfocina; Fosfonomycin; Phosphomycin; phosphomycin disodium salt; Phosphonomycin
Drug Category: Anti-Bacterial Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Fosfomycin: Monurol; Veramina;
Absorption: Fosfomycin tromethamine is rapidly absorbed following oral administration and converted to fosfomycin. Oral bioavailability under fasting conditions is 37%. When given with food, oral bioavailability is reduced to 30%
Toxicity (Overdose): LD₅₀>5 g/kg (rats). Side effects may include diarrhea
Protein Binding: 0% (not bound to plasma proteins)
Biotransformation: No transformation, excreted unchanged
Half Life: 5.7 (± 2.8) hours. The elimination half-life is 40 hours in anuric patients undergoing hemodialysis.
Dosage Forms of Veramina: Powder Oral
Chemical IUPAC Name: [(2R,3S)-3-methyloxiran-2-yl]phosphonic acid
Chemical Formula: C3H7O4P
Fosfomycin on Wikipedia: https://en.wikipedia.org/wiki/Fosfomycin
Organisms Affected: Enteric bacteria and other eubacteria