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Turixin: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Turixin - General Information

Turixin (pseudomonic acid A, or Bactroban or Centany) is an antibiotic originally isolated from Pseudomonas fluorescens. It is used topically, and is primarily effective against Gram-positive bacteria. Turixin is bacteriostatic at low concentrations and bactericidal at high concentrations.
Turixin has a unique mechanism of action, which is selective binding to bacterial isoleucyl-tRNA synthetase, which halts the incorporation of isoleucine into bacterial proteins. Because this mechanism of action is not shared with any other antibiotic, mupirocin has few problems of antibiotic cross-resistance.

 

Pharmacology of Turixin

Turixin, an antibiotic produced from Pseudomonas fluorescens, is structurally unrelated to any other topical or systemic antibiotics. Turixin is used to treat infection caused by Staphylococcus aureus and beta-hemolytic streptococci including Streptococcus pyogenes. This antibiotic has little, if any, potential for cross-resistance with other antibiotics.

 

Turixin for patients

Patients should be given the following instructions:

Apply approximately one-half of the ointment from the single-use tube directly into one nostril and the other half into the other nostril; Avoid contact of the medication with the eyes; Discard the tube after using, do not re-use; Press the sides of the nose together and gently massage after application to spread the ointment throughout the inside of the nostrils; Discontinue usage of the medication and call your health care practitioner if sensitization or severe local irritation occurs.   Turixin Interactions No information provided.   Turixin Contraindications This drug is contraindicated in individuals with a history of sensitivity reactions to any of its components.   Additional information about Turixin Turixin Indication: For the treatment of Staphylococci nasal carriers. Mechanism Of Action: Turixin reversibly binds to bacterial isoleucyl-tRNA synthetase, an enzyme which promotes the conversion of isoleucine and tRNA to isoleucyl-tRNA, resulting in the inhibition of bacterial protein and RNA synthesis. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Mupirocin Synonyms: MRC; Pseudomonic acid; Mupirocine Drug Category: Anti-Bacterial Agents; Antibiotics Drug Type: Small Molecule; Approved Other Brand Names containing Mupirocin: Bactoderm; Bactroban; Bactroban Nasal; Centany; Turixin; Absorption: No measurable systemic absorption Toxicity (Overdose): Not Available Protein Binding: 97% Biotransformation: Hepatic. Following intravenous or oral administration, mupirocin is rapidly metabolized. The principal metabolite is monic acid, which has no antibacterial activity. Half Life: 20 to 40 minutes Dosage Forms of Turixin: Ointment TopicalCream Topical Chemical IUPAC Name: 9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic acid Chemical Formula: C26H44O9 Mupirocin on Wikipedia: https://en.wikipedia.org/wiki/Mupirocin Organisms Affected: Enteric bacteria and other eubacteria