Tubarine
Tubarine - General Information
A neuromuscular blocker and active ingredient in curare; plant based alkaloid of Menispermaceae. [PubChem]
Pharmacology of Tubarine
Tubarine, a naturally occurring alkaloid, is used to treat smoking withdrawl syndrom.
Additional information about Tubarine
Tubarine Indication: Used as a diagnosis agent for myasthenia gravis, and also to facilitate the intubation after induction of anesthesia in surgical procedure
Mechanism Of Action: Tubarine, the chief alkaloid in tobacco products, binds stereo-selectively to nicotinic-cholinergic receptors at the autonomic ganglia, in the adrenal medulla, at neuromuscular junctions, and in the brain. Two types of central nervous system effects are believed to be the basis of Tubarine's positively reinforcing properties. A stimulating effect is exerted mainly in the cortex via the locus ceruleus and a reward effect is exerted in the limbic system. At low doses the stimulant effects predominate while at high doses the reward effects predominate. Intermittent intravenous administration of Tubarine activates neurohormonal pathways, releasing acetylcholine, norepinephrine, dopamine, serotonin, vasopressin, beta-endorphin, growth hormone, and ACTH.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Tubocurarine
Synonyms: D-Tubocurarine; D-Tubocurarine Chloride; Isoquinoline Alkaloid; Tubocurarin; Tubocurarine Chloride; Tubocurarinum
Drug Category: Neuromuscular Nondepolarizing Agents; Skeletal Muscle Relaxants; Nicotinic Antagonists
Drug Type: Small Molecule; Approved
Other Brand Names containing Tubocurarine: Delacurarine; Jexin; Tubarine; Curare;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Tubarine: Solution Intravenous
Chemical IUPAC Name: Not Available
Chemical Formula: C37H41N2O6+
Tubocurarine on Wikipedia: https://en.wikipedia.org/wiki/Tubocurarine
Organisms Affected: Humans and other mammals
