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Tolvan: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Tolvan - General Information

A tetracyclic compound with antidepressant effects. Tolvan was previously available internationally, however in most markets it has been phased out in favor of Mirtazapine.

 

Pharmacology of Tolvan

Tolvan is a tetracyclic antidepressant that has antihistaminic and hypnosedative, but almost no anticholinergic, effect. It is a weak inhibitor of norepinephrine reuptake and strongly stimulates the release of norepinephrine. Interactions with serotonin receptors in the central nervous system have also been found. Its effect is usually noticeable after one to three weeks. Tolvan may cause drowsiness and hematological problems.

 

Additional information about Tolvan

Tolvan Indication: For the treatment of depression. Mechanism Of Action: Tolvan's mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Mianserin Synonyms: Mianseryna [polish]; Mianserinum [inn-latin]; Mianserine [inn-french]; Mianserina [inn-spanish]; Mianserine Drug Category: Adrenergic alpha-Antagonists; Histamine H1 Antagonists; Serotonin Antagonists; Antidepressive Agents, Second-Generation Drug Type: Small Molecule; Approved Other Brand Names containing Mianserin: Bolvidon; Norval; Tolvan; Absorption: Absorbed following oral administration. Toxicity (Overdose): Oral rat LD50: 780mg/kg Protein Binding: 90% Biotransformation: Hepatic. Half Life: 10-17 hours Dosage Forms of Tolvan: Not Available Chemical IUPAC Name: Not Available Chemical Formula: C18H20N2 Mianserin on Wikipedia: https://en.wikipedia.org/wiki/Mianserin Organisms Affected: Humans and other mammals