Tolvan
Tolvan - General Information
A tetracyclic compound with antidepressant effects. Tolvan was previously available internationally, however in most markets it has been phased out in favor of Mirtazapine.
Pharmacology of Tolvan
Tolvan is a tetracyclic antidepressant that has antihistaminic and hypnosedative, but almost no anticholinergic, effect. It is a weak inhibitor of norepinephrine reuptake and strongly stimulates the release of norepinephrine. Interactions with serotonin receptors in the central nervous system have also been found. Its effect is usually noticeable after one to three weeks. Tolvan may cause drowsiness and hematological problems.
Additional information about Tolvan
Tolvan Indication: For the treatment of depression.
Mechanism Of Action: Tolvan's mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Mianserin
Synonyms: Mianseryna [polish]; Mianserinum [inn-latin]; Mianserine [inn-french]; Mianserina [inn-spanish]; Mianserine
Drug Category: Adrenergic alpha-Antagonists; Histamine H1 Antagonists; Serotonin Antagonists; Antidepressive Agents, Second-Generation
Drug Type: Small Molecule; Approved
Other Brand Names containing Mianserin: Bolvidon; Norval; Tolvan;
Absorption: Absorbed following oral administration.
Toxicity (Overdose): Oral rat LD50: 780mg/kg
Protein Binding: 90%
Biotransformation: Hepatic.
Half Life: 10-17 hours
Dosage Forms of Tolvan: Not Available
Chemical IUPAC Name: Not Available
Chemical Formula: C18H20N2
Mianserin on Wikipedia: https://en.wikipedia.org/wiki/Mianserin
Organisms Affected: Humans and other mammals
