Toledomin

Toledomin - General Information

Toledomin is an antidepressant of the serotonin-norepinephrine reuptake inhibitor class. Toledomin has been approved and sold in Austria since September 1998 under the brand name Ixel. Cypress Bioscience bought the exclusive rights for approval and marketing of the drug for any purpose in the US and Canada in 2003 from the manufacturer Pierre Fabre; the approval procedure in both countries is ongoing.

Pharmacology of Toledomin

Not Available

Additional information about Toledomin

Toledomin Indication: Toledomin is used to treat moderate to severe clinical depression and chronic pain.
Mechanism Of Action: Toledomin inhibits norepinephrine and serotonin reuptake in a 3:1 ratio, in practical use this means a balanced (equal) action upon both transmitters. The serotonin reuptake inhibition is likely to improve depression, while the norepinephrine reuptake inihibition probably improves chronic pain. Toledomin exerts no significant actions on postynaptic H1, alpha-1, D1, D2, and muscarinic receptors, as well as on benzodiazepine/opiate binding sites. [Wikipedia]
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Milnacipran
Synonyms: Milnacipranum [latin]; Midalcipran; (-)-milnacipran; F 2207
Drug Category: Antidepressive Agents; Serotonin Uptake Inhibitors; Adrenergic Uptake Inhibitors
Drug Type: Small Molecule; Approved; Investigational

Other Brand Names containing Milnacipran: Ixel; Toledomin;
Absorption: Milnacipran is well absorbed following oral administration with an absolute bioavailability of 85%. Meals have no effect on absorption.
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Only traces of active metabolites are found. Cytochrome P450 enzymes play no role in the metabolism of Milnacipran.
Half Life: 8 hours
Dosage Forms of Toledomin: Not Available
Chemical IUPAC Name: (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide
Chemical Formula: C15H22N2O
Milnacipran on Wikipedia: https://en.wikipedia.org/wiki/Milnacipran
Organisms Affected: Humans and other mammals