Togamycin

Togamycin - General Information

An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea.

Pharmacology of Togamycin

Togamycin is an aminocyclitol antibiotic produced by a species of soil microorganism designated as Streptomyces spectabilis. In vitro studies have shown spectinomycin to be active against most strains of Neisseria gonorrhoeae (minimum inhibitory concentration <7.5 to 20 mcg/mL). Footprint studies indicate that spectinomycin exerts regional effects on ribosomal structure.

Togamycin for patients

Patients should be counseled that antibacterial drugs including TROBICIN Sterile Powder should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When TROBICIN Sterile Powder is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by TROBICIN Sterile Powder or other antibacterial drugs in the future.

Togamycin Interactions

No specific information available.

Togamycin Contraindications

The use of TROBICIN Sterile Powder is contraindicated in patients previously found hypersensitive to it.

Additional information about Togamycin

Togamycin Indication: For use in the treatment of acute gonorrheal urethritis and proctitis in the male and acute gonorrheal cervicitis and proctitis in the female when due to susceptible strains of Neisseria gonorrhoeae.
Mechanism Of Action: Togamycin is an inhibitor of protein synthesis in the bacterial cell; the site of action is the 30S ribosomal subunit. It is bacteriostatic in its action.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Spectinomycin
Synonyms: Espectinomicina [INN-Spanish]; Actinospectacina [Italian]; Antibiotic 2233wp; SCM; Spectinomicina [Italian]; Spectinomycin Di HCl; Spectinomycin HCl/ Sulphate; Spectinomycine [INN-French]; Spectinomycinum [INN-Latin]
Drug Category: Anti-Bacterial Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Spectinomycin: Actinospectacin; Spectam; Togamycin; Trobicin;
Absorption: Rapidly and almost completely absorbed after intramuscular injection.
Toxicity (Overdose): Acute oral toxicity (LD₅₀): >5000 mg/kg [Rat]. Information on overdosage in humans is not available.
Protein Binding: Not significant
Biotransformation: Not Available
Half Life: 1 to 3 hours in patients with normal renal function and 10 to 30 hours in patients with impaired renal function with a creatinine clearance < 20 mL per minute.
Dosage Forms of Togamycin: Powder, for suspension Intramuscular
Chemical IUPAC Name: Not Available
Chemical Formula: C14H24N2O7
Spectinomycin on Wikipedia: https://en.wikipedia.org/wiki/Spectinomycin
Organisms Affected: Enteric bacteria and other eubacteria