Tienamycin

Tienamycin - General Information

Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with cilastatin, a renal dipeptidase inhibitor. [PubChem]

Pharmacology of Tienamycin

Tienamycin is a beta-lactam antibiotic belongings to the subgroup of carbapenems. Tienamycin has a broad spectrum of activity against aerobic and anaerobic Gram positive as well as Gram negative bacteria. It is particularly important for its activity against Pseudomonas aeruginosa and the Enterococcus species. Tienamycin is rapidly degraded by the renal enzyme dehydropeptidase when administered alone, and is always co-administered with cilastatin to prevent this inactivation.

Additional information about Tienamycin

Tienamycin Indication: For the treatment of bacterial infections caused by susceptible bacteria.
Mechanism Of Action: Tienamycin acts as an antimicrobial through inhibiting cell wall synthesis of various gram-positive and gram-negative bacteria. It remains very stable in the presence of beta-lactamase (both penicillinase and cephalosporinase) produced by some bacteria, and is a strong inhibitor of beta-lactamases from some gram-negative bacteria that are resistant to most beta-lactam antibiotics.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Imipenem
Synonyms: IMP; N-formimidoylthienamycin; Imipenem, n-formimidoyl thienamycin; Imipemide
Drug Category: Anti-Bacterial Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Imipenem: Tienamycin;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Renal.
Half Life: 1 hour
Dosage Forms of Tienamycin: Not Available
Chemical IUPAC Name: (5R,6S)-3-[2-(aminomethylideneamino)ethylsulfanyl]-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
Chemical Formula: C12H17N3O4S
Imipenem on Wikipedia: https://en.wikipedia.org/wiki/Imipenem
Organisms Affected: Enteric bacteria and other eubacteria