Theralene

Theralene - General Information

A phenothiazine derivative that is used as an antipruritic. [PubChem]

Pharmacology of Theralene

Theralene (also known as Alimemazine) is a tricyclic antihistamine, similar in structure to the phenothiazine antipsychotics, but differing in the ring-substitution and chain characteristics. Theralene is in the same class of drugs as chlorpromazine (Thorazine) and trifluoperazine (Stelazine); however, unlike the other drugs in this class, trimeprazine is not used clinically as an anti-psychotic. It acts as an anti-histamine, a sedative, and an anti-emetic (anti-nausea). Theralene is used principally as an anti-emetic, to prevent motion sickness or as an anti-histamine in combination with other medications in cough and cold preparations. Tricyclic antihistamines are also structurally-related to the tricyclic antidepressants, explaining the antihistaminergic adverse effects of these two drug classes and also the poor tolerability profile of tricyclic H₁-antihistamines.

Theralene for patients

Prescriber should notify the patient to report an form of confusion, sedation, or hypotension. Inform the patient to avoid driving and other hazardous activity if drowsiness occurs. Also inform the patient to avoid alcohol and other CNS depressants while on trimeprazine.

Theralene Interactions

Barbiturates, narcotics, hyptonics, tricyclic antidepressants, and alcohol can increase CNS depression when administered concomitantly with trimeprazine. Trimeprazine also decreases the effect of heparin and oral anticoagulants, while MAOIs can increase the effect of trimeprazine.

Theralene Contraindications

Contraindicated in hypersensitivity to H₁-receptor antagonists, acute asthma attack, and lower respiratory tract disease.

Additional information about Theralene

Theralene Indication: Used to prevent and relieve allergic conditions which cause pruritus (itching) and urticaria (some allergic skin reactions).
Mechanism Of Action: Theralene competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Trimeprazine
Synonyms: (+-)-Alimemazine; (+-)-Trimeprazine; Alimemazine; Alimemazine S,S-dioxide; Bayer 1219; Oxomemazin; Oxomemazina [INN-Spanish]; Oxomemazine; Methylpromazine; Oxomemazine [DCF:INN]; Oxomemazinum [INN-Latin]; Oxymemazine; Trimeperazine; Trimeprazine 5,5-dioxide; Trimeprazine hemi-(+)tartrate; Trimeprazine Tartrat; Trimeprazine Tartrate
Drug Category: Antipruritics; Phenothiazine Derivatives
Drug Type: Small Molecule; Approved

Other Brand Names containing Trimeprazine: Alimezine; Dosegran; Doxergan; Dysedon; Imakol; Levoprome; Panectyl; Repeltin; Repetin; Temaril; Teralen; Theralene; Vallergan;
Absorption: Well absorbed in the digestive tract.
Toxicity (Overdose): Symptoms of overdose clumsiness or unsteadiness, seizures, severe drowsiness, flushing or redness of face, hallucinations, muscle spasms (especially of neck and back), restlessness, shortness of breath, shuffling walk, tic-like (jerky) movements of head and face, trembling and shaking of hands, and insomnia.
Protein Binding: Not Available
Biotransformation: Hepatic
Half Life: Not Available
Dosage Forms of Theralene: Tablet Oral
Chemical IUPAC Name: N,N,2-trimethyl-3-phenothiazin-10-ylpropan-1-amine
Chemical Formula: C18H22N2S
Trimeprazine on Wikipedia: Not Available
Organisms Affected: Humans and other mammals