Suprane
Suprane - General Information
Suprane is a highly fluorinated methyl ethyl ether used for maintenance of general anaesthesia. Volatile agents such as desflurane may activate GABA channels and hyperpolarize cell membranes. In addition, they may inhibit certain calcium channels and therefore prevent release of neurotransmitters and inhibit glutamate channels. Volatile anesthetics easily partition into cellular membranes and could expand the volume of the cell membrane and subsequently distort channels necessary for sodium ion flux and the development of action potentials necessary for synaptic transmission. Suprane preconditions human myocardium against ischemia through activation of mitochondrial K(ATP) channels, adenosine A1 receptor, and alpha and beta adrenoceptors.
Pharmacology of Suprane
Suprane is a general inhalation anesthetic. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential.
Suprane for patients
Suprane Interactions
No clinically significant adverse interactions with commonly used preanesthetic drugs, or drugs used during anesthesia (muscle relaxants, intravenous agents, and local anesthetic agents) were reported in clinical trials. The effect of desflurane on the disposition of other drugs has not been determined.
Like isoflurane, desflurane does not predispose to premature ventricular arrhythmias in the presence of exogenously infused epinephrine in swine.
Suprane Contraindications
SUPRANE® (desflurane, USP) should not be used in patients with a known or suspected genetic susceptibility to malignant hyperthermia.
Known sensitivity to SUPRANE® (desflurane, USP) or to other halogenated agents.
Additional information about Suprane
Suprane Indication: For use as an inhalation agent for induction and/or maintenance of anesthesia for inpatient and outpatient surgery in adults.
Mechanism Of Action: Suprane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Suprane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Suprane also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor and the glycine receptor.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Desflurane
Synonyms: Desflurano [INN-Spanish]; Desfluranum [INN-Latin]
Drug Category: Anesthetics, Inhalation; Neuroprotective Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Desflurane: Suprane;
Absorption: Rapidly absorbed into the circulation via the lungs following inhalation.
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Minimally biotransformed in the liver in humans (approximately 0.02% of the quantity absorbed).
Half Life: Not Available
Dosage Forms of Suprane: Liquid Respiratory (inhalation)
Chemical IUPAC Name: 2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane
Chemical Formula: C3H2F6O
Desflurane on Wikipedia: https://en.wikipedia.org/wiki/Desflurane
Organisms Affected: Humans and other mammals