Sufenta
Sufenta - General Information
An opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. [PubChem]
Pharmacology of Sufenta
Sufenta is a synthetic opioid analgesic. Sufenta interacts predominately with the opioid mu-receptor. These mu-binding sites are discretely distributed in the human brain, spinal cord, and other tissues. In clinical settings, sufentanil exerts its principal pharmacologic effects on the central nervous system. Its primary actions of therapeutic value are analgesia and sedation. Sufenta may increase the patient's tolerance for pain and decrease the perception of suffering, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Sufenta depresses the respiratory centers, depresses the cough reflex, and constricts the pupils.
Sufenta for patients
Your doctor has ordered sufentanil, a strong analgesic (painkiller), to relieve your pain. The drug will be added to an intravenous fluid that will drip through a needle or catheter placed in your vein. You will probably receive sufentanil continuously for around-the-clock pain relief. Your doctor also may order other pain medications to make you feel more comfortable. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Your health care provider (doctor, nurse, or pharmacist) may measure the effectiveness and side effects of your treatment using laboratory tests and physical examinations. It is important to keep all appointments with your doctor and the laboratory. The length of treatment depends on how you respond to the medication.
Sufenta Interactions
May interact with the following: any other medicine, prescription or nonprescription (over-the-counter [OTC]), or street drugs, such as amphetamines, barbiturates, cocaine, marijuana, phencyclidine, and heroin or other narcotics (serious side effects may occur if anyone gives you an anesthetic without knowing that you have taken another medicine), benzodiazepines, central nervous system (CNS) depressants (the CNS depressant and other effects of either these medicines or the narcotic analgesics may be increased), buprenorphine or similar medicines (the narcotic analgesics may not work if you are taking buprenorphine or other similar medicines), cimetidine, erythromycin (increased chance of side effects with some narcotic analgesics), and naltrexone (the narcotic analgesics will not work if you are taking naltrexone).
Sufenta Contraindications
Contraindicated in the following: abdominal problems, brain tumor, head injury, gallbladder disease, heart disease, kidney disease, liver disease, lung disease, prostate disease, thyroid disease, and urinary tract disease. Narcotic analgesics may make these conditions or the symptoms of these conditions worse.
Additional information about Sufenta
Sufenta Indication: Used as an analgesic adjunct in anesthesia and as a primary anesthetic drug in procedures requiring assisted ventilation and in the relief of pain.
Mechanism Of Action: Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Sufenta's analgesic activity is, most likely, due to its conversion to morphine. Opioids open calcium-dependent inwardly rectifying potassium channels (OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Sufentanil
Synonyms: Sufentanil Citrate; Sufentanilum [Inn-Latin]; Sufentanyl; Sulfentanil Citrate
Drug Category: Anesthetics, Intravenous; Narcotics; Adjuvants, Anesthesia; Analgesics, Opioid; Opiate Agonists
Drug Type: Small Molecule; Approved; Investigational
Other Brand Names containing Sufentanil: Chronogesic; Sufenta;
Absorption: Not Available
Toxicity (Overdose): LD50: 18.7 mg/kg (IV in mice)
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: 265 minutes
Dosage Forms of Sufenta: Solution Epidural
Liquid Intravenous
Chemical IUPAC Name: N-[4-(methoxymethyl)-1-(2-thiophen-2-ylethyl)piperidin-4-yl]-N-phenylpropanamide
Chemical Formula: C22H30N2O2S
Sufentanil on Wikipedia: https://en.wikipedia.org/wiki/Sufentanil
Organisms Affected: Humans and other mammals
