Stilbiocina

Stilbiocina - General Information

An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Stilbiocina binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189) [PubChem]

Pharmacology of Stilbiocina

Stilbiocina is an aminocoumarin antibiotic that was produced by the actinomycete Streptomyces niveus. Stilbiocina binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. Other antibiotics in the aminocoumarin class include coumermycin A1 and clorobiocin.

Additional information about Stilbiocina

Stilbiocina Indication: For the treatment of infections due to staphylococci and other susceptible organisms
Mechanism Of Action: Stilbiocina is an aminocoumarin. Aminocoumarins are very potent inhibitors of bacterial DNA gyrase and work by targeting the GyrB subunit of the enzyme involved in energy tranduction. Stilbiocina as well as the other aminocoumarin antibiotics act as competitive inhibitors of the ATPase reaction catalysed by GyrB.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Novobiocin
Synonyms: Novobiocina [Inn-Spanish]; Novobiocine [Inn-French]; Novobiocinum [Inn-Latin]; NOV; Crystallinic Acid; Antibiotic Pa-93
Drug Category: Anti-Bacterial Agents; Enzyme Inhibitors; Nucleic Acid Synthesis Inhibitors
Drug Type: Small Molecule; Approved

Other Brand Names containing Novobiocin: Albamix; Cardelmycin; Cathocin; Cathomycin; Inamycin; Novo-R; Robiocina; Sirbiocina; Spheromycin; Stilbiocina; Streptonivicin; Albamycin;
Absorption: Oral bioavailability is negligible.
Toxicity (Overdose): Not Available
Protein Binding: 95%
Biotransformation: Not Available
Half Life: 6 hours
Dosage Forms of Stilbiocina: Injection, powder, for solution Intravenous
Chemical IUPAC Name: [(3R,4S,5R,6R)-5-hydroxy-6-[2-hydroxy-3-[[4-hydroxy-3-(3-methylbut-2-enyl)benzoyl]amino]-8-methyl-4-oxochromen-7-yl]oxy-3-methoxy-2,2-dimethyloxan-4-yl] carbamate
Chemical Formula: C31H36N2O11
Novobiocin on Wikipedia: https://en.wikipedia.org/wiki/Novobiocin
Organisms Affected: Enteric bacteria and other eubacteria