Sotradecol

Sotradecol - General Information

An anionic surface-active agent used for its wetting properties in industry and used in medicine as an irritant and sclerosing agent for hemorrhoids and varicose veins.

Pharmacology of Sotradecol

Sodium tetradecyl sulfate is an anionic surfactant which occurs as a white, waxy solid. It is used as a sclerosing agent in sclerotherapy. Sclerotherapy is an injection of a sclerosing agent directly through the skin into a lesion and is used primarily for slow-flow vascular anomalies, particularly for venous malformation and lymphatic malformation. Intravenous injection causes intima inflammation and thrombus formation. This usually occludes the injected vein. Subsequent formation of fibrous tissue results in partial or complete vein obliteration that may or may not be permanent.

Sotradecol for patients

Sotradecol Interactions

Interactions for Sodium Tetradecyl Sulfate:

No well-controlled studies have been performed on patients taking antiovulatory agents. The physician must use judgment and evaluate any patient taking antiovulatory drugs prior to initiating treatment with Sotradecol.

Heparin should not be included in the same syringe as Sodium Tetradecyl Sulfate, since the two are incompatible.

Sotradecol Contraindications

Contraindications for Sodium Tetradecyl Sulfate:

Sodium Tetradecyl Sulfate is contraindicated in previous hypersensitivity reactions to the drug; in acute superficial thrombophlebitis; valvular or deep vein incompetence; huge superficial veins with wide open communications to deeper veins; phlebitis migrans; acute cellulitis; allergic conditions; acute infections; varicosities caused by abdominal and pelvic tumors unless the tumor has been removed; bedridden patients; such uncontrolled systemic diseases as diabetes, toxic hyperthyroidism, tuberculosis, asthma, neoplasm, sepsis, blood dyscrasias and acute respiratory or skin diseases.

Additional information about Sotradecol

Sotradecol Indication: For the treatment of small uncomplicated varicose veins of the lower extremities that show simple dilation with competent valves.
Mechanism Of Action: Sodium tetradecyl sulfate is a potent toxin for endothelial cells in that brief exposure to even low concentrations are effective in stripping endothelium over a considerable distance and exposing highly thrombogenic endothelium in the process. Diluted sodium tetradecyl sulfate is also able to induce a hypercoagulable state, possibly by selective inhibition of protein C, and can also promote platelet aggregation.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Sodium Tetradecyl Sulfate
Synonyms: Tetradecyl sulfuric Acid; Tetradecyl sulfate; Tetradecyl sodium sulfate; Tetradecyl hydrogen sulphate; Sodium myristyl sulfate; S.T.D.; STD; Monotetradecylsulfate sodium salt
Drug Category: Surface-Active Agents; Sclerosing Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Sodium Tetradecyl Sulfate: Niaproof-4; Tergitol-4; Texapon K 14; Sotradecol;
Absorption: Not Available
Toxicity (Overdose): LD₅₀=1250 mg/kg (Orally in rat); LD₅₀=3 ml/kg (Skin in rat)
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Sotradecol: Solution Intravenous
Chemical IUPAC Name: sodium tetradecyl sulfate
Chemical Formula: C14H29NaO4S
Sodium Tetradecyl Sulfate on Wikipedia: Not Available
Organisms Affected: Humans and other mammals