Silvadene

Silvadene - General Information

Silvadene is a sulfa derivative topical antibacterial used primarily on second- and third-degree burns. [Wikipedia]

Pharmacology of Silvadene

Silvadene has broad antimicrobial activity. It is bactericidal for many gram- negative and gram-positive bacteria as well as being effective against yeast. Silvadene is not a carbonic anhydrase inhibitor and may be useful in situations where such agents are contraindicated.

Additional information about Silvadene

Silvadene Indication: Indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns.
Mechanism Of Action: Studies utilizing radioactive micronized silver sulfadiazine, electron microscopy, and biochemical techniques have revealed that the mechanism of action of silver sulfadiazine on bacteria differs from silver nitrate and sodium sulfadiazine. Silvadene acts only on the cell membrane and cell wall to produce its bactericidal effect.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Silver sulfadiazine
Synonyms: Sulfadiazine silver; SSD; Silver sulfadiazinate; Silver sulphadiazine
Drug Category: Antibacterial Agents; Topical Antibiotic; Anti-Infective Agents, Local
Drug Type: Small Molecule; Approved

Other Brand Names containing Silver sulfadiazine: Silvadene; Thermazene; SSD (1% Silver Sulfadiazine Cream USP); Dermazin; Flamazine; Sildaflo;
Absorption: Very limited penetration through the skin. Only when applied to very large area burns is absorption into the body generally an issue.
Toxicity (Overdose): Acute oral toxicity (LD50) in rat is 10001 mg/kg.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Silvadene: Cream Topical
Chemical IUPAC Name: silver (4-aminophenyl)sulfonyl-pyrimidin-2-ylazanide
Chemical Formula: C10H9AgN4O2S
Silver sulfadiazine on Wikipedia: https://en.wikipedia.org/wiki/Silver_sulfadiazine
Organisms Affected: Various gram-negative and gram-positive eubacteria; Yeast and other fungi