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Serdolect: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Serdolect - General Information

Serdolect, a neuroleptic, is one of the newer antipsychotic medications available. Serdolect is developed by the Danish pharmaceutical company H. Lundbeck. Like the other atypical antipsychotics, it has activity at dopamine and serotonin receptors in the brain. It is used in the treatment of schizophrenia. It is classified chemically as a phenylindole derivative. It was first marketed in 1996 in several European countries before being withdrawn two years later because of numerous cardiac adverse effects. It has once again been approved and should soon be available on the French and Australian market.

 

Pharmacology of Serdolect

Serdolect is an atypical antipsychotic at least as effective as haloperidol and risperidone in the treatment of neuroleptic-responsive schizophrenia. Serdolect improves negative symptoms, and is also effective for the treatment of neuroleptic-resistant schizophrenia. Serdolect is generally well tolerated and is associated with a low rate of extrapyramidal symptoms (EPS).

 

Additional information about Serdolect

Serdolect Indication: Used in the treatment of schizophrenia. Mechanism Of Action: Serdolect is an antipsychotic drug with affinity for dopamine D2, serotonin 5-HT2A and 5-HT2C, and alpha1-adrenoreceptors. Preclinical studies suggest that sertindole acts preferentially on limbic and cortical dopaminergic neurons and clinical trials have confirmed that sertindole is effective at a low dopamine D2 occupancy level. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Sertindole Synonyms: Sertindol [inn-spanish]; Sertindolum [inn-latin] Drug Category: Antipsychotic Agents; Neuroleptics Drug Type: Small Molecule; Approved Other Brand Names containing Sertindole: Serdolect; Serlect; Absorption: Orally available. Toxicity (Overdose): Not Available Protein Binding: Not Available Biotransformation: Hepatic. Sertindole is metabolized by cytochrome P450 isoenzymes CYP 2D6 and CYP 3A4. Half Life: 3 days Dosage Forms of Serdolect: Not Available Chemical IUPAC Name: 1-[2-[4-[5-chloro-1-(4-fluorophenyl)indol-3-yl]piperidin-1-yl]ethyl]imidazolidin-2-one Chemical Formula: C24H26ClFN4O Sertindole on Wikipedia: https://en.wikipedia.org/wiki/Sertindole Organisms Affected: Humans and other mammals