Serdolect

Serdolect - General Information

Serdolect, a neuroleptic, is one of the newer antipsychotic medications available. Serdolect is developed by the Danish pharmaceutical company H. Lundbeck. Like the other atypical antipsychotics, it has activity at dopamine and serotonin receptors in the brain. It is used in the treatment of schizophrenia. It is classified chemically as a phenylindole derivative. It was first marketed in 1996 in several European countries before being withdrawn two years later because of numerous cardiac adverse effects. It has once again been approved and should soon be available on the French and Australian market.

Pharmacology of Serdolect

Serdolect is an atypical antipsychotic at least as effective as haloperidol and risperidone in the treatment of neuroleptic-responsive schizophrenia. Serdolect improves negative symptoms, and is also effective for the treatment of neuroleptic-resistant schizophrenia. Serdolect is generally well tolerated and is associated with a low rate of extrapyramidal symptoms (EPS).

Additional information about Serdolect

Serdolect Indication: Used in the treatment of schizophrenia.
Mechanism Of Action: Serdolect is an antipsychotic drug with affinity for dopamine D2, serotonin 5-HT2A and 5-HT2C, and alpha1-adrenoreceptors. Preclinical studies suggest that sertindole acts preferentially on limbic and cortical dopaminergic neurons and clinical trials have confirmed that sertindole is effective at a low dopamine D2 occupancy level.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Sertindole
Synonyms: Sertindol [inn-spanish]; Sertindolum [inn-latin]
Drug Category: Antipsychotic Agents; Neuroleptics
Drug Type: Small Molecule; Approved

Other Brand Names containing Sertindole: Serdolect; Serlect;
Absorption: Orally available.
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Hepatic. Sertindole is metabolized by cytochrome P450 isoenzymes CYP 2D6 and CYP 3A4.
Half Life: 3 days
Dosage Forms of Serdolect: Not Available
Chemical IUPAC Name: 1-[2-[4-[5-chloro-1-(4-fluorophenyl)indol-3-yl]piperidin-1-yl]ethyl]imidazolidin-2-one
Chemical Formula: C24H26ClFN4O
Sertindole on Wikipedia: https://en.wikipedia.org/wiki/Sertindole
Organisms Affected: Humans and other mammals