Rocephine
Rocephine - General Information
A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears. [PubChem]
Pharmacology of Rocephine
Rocephine is a cephalosporin/cephamycin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. Rocephine has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Rocephine results from the inhibition of cell wall synthesis and is mediated through Rocephine binding to penicillin binding proteins (PBPs). Rocephine is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.
Rocephine for patients
Patient Information:
Patients should be counseled that antibacterial drugs including Ceftriaxone should only be used to
treat bacterial infections. They do not treat viral infections (eg, common cold). When Ceftriaxone
is prescribed to treat a bacterial infection, patients should be told that although it is common
to feel better early in the course of therapy, the medication should be taken exactly as directed.
Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of
the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and
will not be treatable by Ceftriaxone or other antibacterial drugs in the future.
Rocephine Interactions
No information provided.
Rocephine Contraindications
Rocephin is contraindicated in patients with known allergy to the cephalosporin class of antibiotics.
Additional information about Rocephine
Rocephine Indication: For the treatment of the infections (respiratory, skin, soft tissue, UTI, ENT) caused by S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph
Mechanism Of Action: Rocephine works by inhibiting the mucopeptide synthesis in the bacterial cell wall. The beta-lactam moiety of Rocephine binds to carboxypeptidases, endopeptidases, and transpeptidases in the bacterial cytoplasmic membrane. These enzymes are involved in cell-wall synthesis and cell division. By binding to these enzymes, Rocephine results in the formation of of defective cell walls and cell death.
Drug Interactions: Amikacin Increased risk of nephrotoxicity
Gentamicin Increased risk of nephrotoxicity
Anisindione The cephalosporin increases the anticoagulant effect
Dicumarol The cephalosporin increases the anticoagulant effect
Acenocoumarol The cephalosporin increases the anticoagulant effect
Warfarin The cephalosporin increases the anticoagulant effect
Kanamycin Increased risk of nephrotoxicity
Neomycin Increased risk of nephrotoxicity
Netilmicin Increased risk of nephrotoxicity
Streptomycin Increased risk of nephrotoxicity
Tobramycin Increased risk of nephrotoxicity
Food Interactions: Not Available
Generic Name: Ceftriaxone
Synonyms: Ceftriaxona [Inn-Spanish]; Ceftriaxonum [Inn-Latin]; Cefatriaxone; Ceftriazone
Drug Category: Anti-Bacterial Agents; Cephalosporins
Drug Type: Small Molecule; Approved
Other Brand Names containing Ceftriaxone: Biotrakson; Rocephine;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: 95%
Biotransformation: Not Available
Half Life: 5.8-8.7 hours
Dosage Forms of Rocephine: Powder, for solution Intravenous
Chemical IUPAC Name: (6R,7R)-7-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-5,6-dioxo-1H-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Chemical Formula: C18H18N8O7S3
Ceftriaxone on Wikipedia: https://en.wikipedia.org/wiki/Ceftriaxone
Organisms Affected: Enteric bacteria and other eubacteria
