Rautensin: Full Drug Profile

Rautensin - General Information

A fat-soluble alkaloidal fraction extracted from the root of Rauwolfia serpentina, containing reserpine and other nonadrenolytic amorphous alkaloids; used as a sedative in psychoses, in mild hypertension, and as an adjunct to more potent hypotensive drugs.

Pharmacology of Rautensin

Rautensin is a purified extract of Rauwolfia serpentina, containing reserpine and other amorphous alkaloids. Rautensin is an indole alkaloid antipsychotic and antihypertensive drug known to irreversibly bind to storage vesicles of neurotransmitters such as dopamine, norepinephrine, and serotonin. This leads to depletion of the neurotransmitters and subsequent depression in humans.

Additional information about Rautensin

Rautensin Indication

For the treatment of hypertension and as an adjunct in the management of angina pectoris.

Mechanism Of Action

The antihypertensive actions of alseroxylon are a result of its ability to deplete catecholamines from peripheral sympathetic nerve endings. Rautensin almost irreversibly blocks the accumulation of noradrenaline and dopamine into synaptic vesicles by inhibiting the Vesicular Monoamine Transporters (VMAT).

Generic Name

Alseroxylon

Drug Category

Adrenergic Uptake Inhibitors

Drug Type

Small Molecule; Approved

Other Brand Names containing Alseroxylon

Rautensin; Rauwiloid;

Dosage Forms of Rautensin

Tablet Oral

Chemical Formula

C33H40N2O9

Organisms Affected

Humans and other mammals