Pyopen
Pyopen - General Information
Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function. [PubChem]
Pharmacology of Pyopen
Pyopen is a semisynthetic penicillin. Though carbenicillin provides substantial in vitro activity against a variety of both gram-positive and gram-negative microorganisms, the most important aspect of its profile is in its antipseudomonal and antiproteal activity. Because of the high urine levels obtained following administration, carbenicillin has demonstrated clinical efficacy in urinary infections due to susceptible strains of: Escherichia coli, Proteus mirabilis, Proteus vulgaris, Morganella morganii, Pseudomonas species, Providencia rettgeri, Enterobacter species, and Enterococci (S. faecalis).
Pyopen for patients
Patients should be counseled that antibacterial drugs including Geocillin should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When Geocillin is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by Geocillin or other antibacterial drugs in the future.
Pyopen Interactions
Geocillin (carbenicillin indanyl sodium) blood levels may be increased and prolonged by concurrent administration of probenecid.
Pyopen Contraindications
Geocillin is ordinarily contraindicated in patients who have a known penicillin allergy.
Additional information about Pyopen
Pyopen Indication: For the treatment of acute and chronic infections of the upper and lower urinary tract and in asymptomatic bacteriuria due to susceptible strains of bacteria.
Mechanism Of Action: Free carbenicillin is the predominant pharmacologically active fraction of the salt. Pyopen exerts its antibacterial activity by interference with final cell wall synthesis of susceptible bacteria. Penicillins acylate the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation of the enzyme prevents the formation of a cross-link of two linear peptidoglycan strands, inhibiting the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that carbenicillin interferes with an autolysin inhibitor.
Drug Interactions: Methotrexate The penicillin increases the effect and toxicity of methotrexate
Anisindione The IV penicillin increases the anticoagulant effect
Demeclocycline Possible antagonism of action
Dicumarol The IV penicillin increases the anticoagulant effect
Acenocoumarol The IV penicillin increases the anticoagulant effect
Doxycycline Possible antagonism of action
Warfarin The IV penicillin increases the anticoagulant effect
Ethinyl Estradiol This anti-infectious agent could decreases the effect of the oral contraceptive
Mestranol This anti-infectious agent could decreases the effect of the oral contraceptive
Methacycline Possible antagonism of action
Minocycline Possible antagonism of action
Oxytetracycline Possible antagonism of action
Rolitetracycline Possible antagonism of action
Tetracycline Possible antagonism of action
Food Interactions: Take on an empty stomach.
Generic Name: Carbenicillin
Synonyms: Carboxybenzylpenicillin acid; Carboxybenzylpenicillin; Carbenicillinum [INN-Latin]; Carbenicilline [INN-French]; Carbenicillina [DCIT]; Carbenicilina [INN-Spanish]; alpha-Carboxybenzylpencillin
Drug Category: Anti-Bacterial Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Carbenicillin: Geopen; Pyopen;
Absorption: Rapidly absorbed from the small intestine following oral administration. Oral bioavailability is 30 to 40%.
Toxicity (Overdose): Carbenicillin blood levels achievable are very low, and toxic reactions as a function of overdosage should not occur systematically. The oral LD50 in mice is 3,600 mg/kg, in rats 2,000 mg/kg, and in dogs is in excess of 500 mg/kg. The lethal human dose is not known. Symptoms of overdose include diarrhea, nausea, stomach upset, and vomiting.
Protein Binding: 30 to 60%
Biotransformation: Minimal.
Half Life: 1 hour
Dosage Forms of Pyopen: Tablet, film coated Oral
Chemical IUPAC Name: (2S,5R,6R)-6-[(3-hydroxy-3-oxo-2-phenylpropanoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Chemical Formula: C17H18N2O6S
Carbenicillin on Wikipedia: https://en.wikipedia.org/wiki/Carbenicillin
Organisms Affected: Enteric bacteria and other eubacteria
