Propethonum: Full Drug Profile

Propethonum - General Information

Propethonum is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. Propethonum is an antimuscarinic, anticholinergic drug.

Pharmacology of Propethonum

Propethonum is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. Propethonum is an antimuscarinic, anticholinergic drug.

Additional information about Propethonum

Propethonum Indication

Used as an adjunct in the treatment of peptic ulcer disease

Mechanism Of Action

Propethonum binds the muscarinic acetylcholine receptor. It may block all three types of muscarinic receptors including M-1 receptors in the CNS and ganglia, M-2 receptors in the heart (vagus) and M-3 receptors at the parasympathetic NEJ system. The muscarinic acetylcholine receptors mediate various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Propethonum inhibits vagally mediated reflexes by antagonizing the action of acetylcholine. This in turn reduces the secretion of gastric acids in the stomach.

Generic Name

Tridihexethyl

Drug Category

Antispasmodics; Anticholinergic Agents

Drug Type

Small Molecule; Approved

Other Brand Names containing Tridihexethyl

Pathilon; Propethonum;

Chemical IUPAC Name

(3-cyclohexyl-3-hydroxy-3-phenylpropyl)-triethylazanium

Chemical Formula

C21H36NO+

Organisms Affected

Humans and other mammals