Pressyn
Pressyn - General Information
Antidiuretic hormone, also known as vasopressin, is a nine amino acid peptide secreted from the posterior pituitary. Antidiuretic hormone binds to receptors in the distal or collecting tubules of the kidney and promotes reabsorbtion of water back into the circulation
Pharmacology of Pressyn
Pressyn is an antidiuretic hormone indicated for the prevention and treatment of postoperative abdominal distention, in abdominal roentgenography to dispel interfering gas shadows, and in diabetes insipidus. Pressyn can cause contraction of smooth muscle of the gastrointestinal tract and of all parts of the vascular bed, especially the capillaries, small arterioles and venules. It has less effect on the smooth musculature of the large veins. Pressyn may also be used to control bleeding in some forms of von Willebrand disease and to treat extreme cases of bed wetting in children. It may also play a role in memory formation although the mechanism is unknown.
Pressyn for patients
Side effects such as blanching of skin, abdominal cramps, and nausea may be reduced by taking 1 or 2 glasses of water at the time of vasopressin administration. These side effects are usually not serious and probably will disappear within a few minutes.
Pressyn Interactions
- The following drugs may potentiate the antidiuretic effect of vasopressin when used concurrently: carbamazepine; chlorpropamide; clofibrate; urea; fludrocortisone; tricyclic antidepressants.
- The following drugs may decrease the antidiuretic effect of vasopressin when used concurrently: demeclocyline; norepinephrine; lithium; heparin, alcohol.
- Ganglionic blocking agents may produce a marked increase in sensitivity to the pressor effects of vasopressin.
Pressyn Contraindications
Anaphylaxis or hypersensitivity to the drug or its components.
Additional information about Pressyn
Pressyn Indication: For the treatment of enuresis, polyuria, diabetes insipidus, polydipsia and oesophageal varices with bleeding
Mechanism Of Action: Pressyn acts on three different receptors, vasopressin receptor V1a (which initiates vasoconstriction, liver gluconeogenesis, platelet aggregation and release of factor VIII), vasopressin receptor V1b (which mediates corticotrophin secretion from the pituitary) and vasopressin receptor V2 which controls free water reabsorption in the renal medullar. The binding of vasopressin to the V2 receptor activates adenylate cyclase which causes the release of aquaporin 2 channels into the cells lining the renal medullar duct. This allows water to be reabsorbed down an osmotic gradient so the urine is more concentrated.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Vasopressin
Synonyms: 3-Isoleucyl vasopressin; Arginine oxytocin; Arginine vasotocin; Argiprestocin; Pitressin tannate; Vasopressin, isoleucyl; Vasopressin, non-mammalian; Vasotocin
Drug Category: Antidiuretics; Vasoconstrictor Agents
Drug Type: Biotech; Approved
Other Brand Names containing Vasopressin: Pitressin; Pressyn;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: 1%
Biotransformation: The majority of a dose of vasopressin is metabolized and rapidly destroyed in the liver and kidneys.
Half Life: 10-20 minutes
Dosage Forms of Pressyn: Liquid Intramuscular
Solution Intramuscular
Chemical IUPAC Name: 1-[19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-butan-2-yl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pyrrolidine-2-carboxamide
Chemical Formula: C43H67N15O12S2
Vasopressin on Wikipedia: https://en.wikipedia.org/wiki/Vasopressin
Organisms Affected: Humans and other mammals
