Precef
Precef - General Information
Precef is a second-generation parenteral cephalosporin antibiotic. It has a longer elimination half-life than any currently available cephalosporin. Its activity is very similar to that of cefamandole, a second-generation cephalosporin, except that ceforanide is less active against most gram-positive organisms. Many coliforms, including Escherichia coli, Klebsiella, Enterobacter, and Proteus, are susceptible to ceforanide, as are most strains of Salmonella, Shigella, Hemophilus, Citrobacter and Arizona species.
Pharmacology of Precef
Precef is a semisynthetic second-generation cephalosporin. The cephalosporins are bactericidal drugs with both gram-positive and gram-negative activity. They inhibit bacterial cell wall synthesis in a way similar to the penicillins.
Additional information about Precef
Precef Indication: For the treatment of infections caused by susceptible organisms.
Mechanism Of Action: The bactericidal activity of ceforanide results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Ceforanide
Synonyms: Ceforanido [INN-Spanish]; Ceforanidum [INN-Latin]
Drug Category: Anti-Bacterial Agents; Cephalosporins
Drug Type: Small Molecule; Approved
Other Brand Names containing Ceforanide: Precef;
Absorption: Rapidly absorbed following intramuscular injection.
Toxicity (Overdose): Adverse effects following overdosage include nausea, vomiting, epigastric distress, diarrhea, and convulsions.
Protein Binding: 80.6%
Biotransformation: The major drug elimination route was urinary excretion with 85% of the dose being excreted unchanged in the urine within 12 hr, and no metabolites with antibiotic activity were observed in urine.
Half Life: 2.6 to 2.98 hours
Dosage Forms of Precef: Not Available
Chemical IUPAC Name: (6R,7R)-7-[[2-[2-(aminomethyl)phenyl]acetyl]amino]-3-[[1-(carboxymethyl)tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Chemical Formula: C20H21N7O6S2
Ceforanide on Wikipedia: https://en.wikipedia.org/wiki/Ceforanide
Organisms Affected: Enteric bacteria and other eubacteria
