Pre-pen: Full Drug Profile

Pre-pen - General Information

Pre-pen is used as a skin-testing reagent to detect immunoglobulin E antibodies in people with a history of penicillin allergy. The quantitation of in vitro IgE antibodies to the benzylpenicilloyl determinant is a useful tool for evaluating allergic subjects.

 

Pharmacology of Pre-pen

Benylpenicilloyl polylysine is penicilloyl bound to polylysine and is considered to be the major determinant of penicillin metabolism; it is used as a skin-testing reagent to detect immunoglobulin E antibodies in people with a history of penicillin allergy. If skin testing using benzylpenicilloyl and penicillin G (as the sole source of minor determinants) is negative, approximately 97% of patients with a negative skin test will tolerate penicillin.

 

Pre-pen for patients

 

Pre-pen Interactions

 

Pre-pen Contraindications

Skin testing for detection of reagin with specific haptenes is never without risk. Skin testing patients known to be extremely hypersensitive to penicillin should not be done unless there is a very strong medical reason for administering penicillin.

 

Additional information about Pre-pen

Pre-pen Indication

For use as a adjunct in assessing the risk of administering penicillin (benzylpenicillin or penicillin G).

Mechanism Of Action

The skin test for penicillin demonstrates the presence or absence of specific IgE antibodies to major and minor penicillin determinants. IgE antibodies to major determinants can be detected by using benzylpenicilloyl polylysine. A penicillin skin test predicts only the presence of IgE antibodies for the major or minor penicillin determinants at the time of application and does not predict the future development of IgE-mediated reactions during subsequent courses of penicillin. Benzylpenicilloyl polylysine reacts specifically with penicilloyl skin sensitizing antibodies (reagins) to produce immediate wheal and flare reactions which may reflect increased risk of allergic reactions to subsequent penicillin therapy.

Generic Name

Benzylpenicilloyl Polylysine

Drug Type

Small Molecule; Approved

Other Brand Names containing Benzylpenicilloyl Polylysine

Pre-pen;

Toxicity (Overdose)

Symptoms of overdose include urticaria, generalized pruritus, local swelling, generalized flushing, anaphylaxis, bronchospasm, fainting and maculopapular eruption.

Dosage Forms of Pre-pen

Liquid Intradermal

Chemical IUPAC Name

2-[2-[(6-hydroxy-6-oxohexyl)amino]-2-oxo-1-[(2-phenylacetyl)amino]ethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid

Chemical Formula

C22H31N3O6S

Organisms Affected

Humans and other mammals