Prantal: Full Drug Profile

Prantal - General Information

Prantal is a quaternary ammonium anticholinergic. It binds muscarinic acetycholine receptors and thereby decreases secretory excretion of stomach acids as well as saliva and sweat.

Pharmacology of Prantal

Prantal is a quaternary ammonium anticholinergic. It binds muscarinic acetycholine receptors and thereby decreases secretory excretion of stomach acids as well as saliva and sweat.

Additional information about Prantal

Prantal Indication

Used in the treatment of peptic ulcer, gastric hyperacidity, and hypermotility in gastritis and pylorospasm, and in the treatment of hyperhidrosis (excessive perspiration).

Mechanism Of Action

Prantal exerts its action by primarily binding the muscarinic M3 receptor. M3 receptors are located in the smooth muscles of the blood vessels, as well as in the lungs. This means they cause vasodilation and bronchoconstriction. They are also in the smooth muscles of the gastrointestinal tract (GIT), which help in increasing intestinal motility and dilating sphincters. The M3 receptors are also located in many glands which help to stimulate secretion in salivary glands and other glands of the body.

Generic Name

Diphemanil Methylsulfate

Drug Category

Bronchodilator Agents; Muscarinic Antagonists; Parasympatholytics

Drug Type

Small Molecule; Approved

Other Brand Names containing Diphemanil Methylsulfate

Prantal;

Absorption

Poorly absorbed from the gastrointestinal tract with an absolute bioavailability of 15 to 25%.

Chemical IUPAC Name

4-benzhydrylidene-1,1-dimethylpiperidin-1-ium; methyl sulfate

Chemical Formula

C21H27NO4S

Organisms Affected

Humans and other mammals