Pondocillin

Pondocillin - General Information

Pivalate ester analog of ampicillin.

Pharmacology of Pondocillin

Pondocillin is the pivaloyloxymethyl ester of (the semi-synthetic penicillin) ampicillin. It is an inactive pro-drug, which is converted during its absorption from the gastrointestinal tract to the microbiologically active ampicillin, together with formaldehyde and pivalic acid, by non-specific esterases present in most body tissues. Amounts in excess of 99% of the pivampicillin absorbed are converted to ampicillin within 15 minutes of absorption.

Additional information about Pondocillin

Pondocillin Indication: or the treatment of respiratory tract infections (including acute bronchitis, acute exacerbations of chronic bronchitis and pneumonia); ear, nose and throat infections; gynecological infections; urinary tract infections (including acute uncomplicated gonococcal urethritis) when caused by non penicillinase-producing susceptible strains of the following organisms: gram-positive organisms, e.g., streptococci, pneumococci and staphylococci; gram-negative organisms, e.g., H. influenzae, N. gonorrhoeae, E. coli, P. mirabilis.
Mechanism Of Action: Ampicillin (the active metabolite of pivampicillin) has a bactericidal action resulting from inhibition of cell wall mucopeptide biosynthesis.
Drug Interactions: Methotrexate The penicillin increases the effect and toxicity of methotrexate
Demeclocycline Possible antagonism of action
Doxycycline Possible antagonism of action
Tetracycline Possible antagonism of action
Rolitetracycline Possible antagonism of action
Oxytetracycline Possible antagonism of action
Minocycline Possible antagonism of action
Methacycline Possible antagonism of action
Ethinyl Estradiol This anti-infectious agent could decrease the effect of the oral contraceptive
Mestranol This anti-infectious agent could decrease the effect of the oral contraceptive
Food Interactions: Not Available
Generic Name: Pivampicillin
Synonyms: Ampicillin pivaloyloxymethyl ester; Pivaloylampicillin; Pivaloyloxymethyl ampicillinate; Pivampicilina [inn-spanish]; Pivampicilline [inn-french]; Pivampicillinum [inn-latin]
Drug Category: Anti-Bacterial Agents; Penicillins
Drug Type: Small Molecule; Approved

Other Brand Names containing Pivampicillin: Pondocillin;
Absorption: Absorbed following oral administration.
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Approximately 1 hour.
Dosage Forms of Pondocillin: Tablet Oral
Chemical IUPAC Name: 2,2-dimethylpropanoyloxymethyl (2S,5R,6R)-6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
Chemical Formula: C22H29N3O6S
Pivampicillin on Wikipedia: https://en.wikipedia.org/wiki/Pivampicillin
Organisms Affected: Enteric bacteria and other eubacteria