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Pondocillin: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Pondocillin - General Information

Pivalate ester analog of ampicillin.

 

Pharmacology of Pondocillin

Pondocillin is the pivaloyloxymethyl ester of (the semi-synthetic penicillin) ampicillin. It is an inactive pro-drug, which is converted during its absorption from the gastrointestinal tract to the microbiologically active ampicillin, together with formaldehyde and pivalic acid, by non-specific esterases present in most body tissues. Amounts in excess of 99% of the pivampicillin absorbed are converted to ampicillin within 15 minutes of absorption.

 

Additional information about Pondocillin

Pondocillin Indication: or the treatment of respiratory tract infections (including acute bronchitis, acute exacerbations of chronic bronchitis and pneumonia); ear, nose and throat infections; gynecological infections; urinary tract infections (including acute uncomplicated gonococcal urethritis) when caused by non penicillinase-producing susceptible strains of the following organisms: gram-positive organisms, e.g., streptococci, pneumococci and staphylococci; gram-negative organisms, e.g., H. influenzae, N. gonorrhoeae, E. coli, P. mirabilis. Mechanism Of Action: Ampicillin (the active metabolite of pivampicillin) has a bactericidal action resulting from inhibition of cell wall mucopeptide biosynthesis. Drug Interactions: Methotrexate The penicillin increases the effect and toxicity of methotrexateDemeclocycline Possible antagonism of actionDoxycycline Possible antagonism of actionTetracycline Possible antagonism of actionRolitetracycline Possible antagonism of actionOxytetracycline Possible antagonism of actionMinocycline Possible antagonism of actionMethacycline Possible antagonism of actionEthinyl Estradiol This anti-infectious agent could decrease the effect of the oral contraceptiveMestranol This anti-infectious agent could decrease the effect of the oral contraceptive Food Interactions: Not Available Generic Name: Pivampicillin Synonyms: Ampicillin pivaloyloxymethyl ester; Pivaloylampicillin; Pivaloyloxymethyl ampicillinate; Pivampicilina [inn-spanish]; Pivampicilline [inn-french]; Pivampicillinum [inn-latin] Drug Category: Anti-Bacterial Agents; Penicillins Drug Type: Small Molecule; Approved Other Brand Names containing Pivampicillin: Pondocillin; Absorption: Absorbed following oral administration. Toxicity (Overdose): Not Available Protein Binding: Not Available Biotransformation: Not Available Half Life: Approximately 1 hour. Dosage Forms of Pondocillin: Tablet Oral Chemical IUPAC Name: 2,2-dimethylpropanoyloxymethyl (2S,5R,6R)-6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate Chemical Formula: C22H29N3O6S Pivampicillin on Wikipedia: https://en.wikipedia.org/wiki/Pivampicillin Organisms Affected: Enteric bacteria and other eubacteria