PhosLo: Full Drug Profile
PhosLo - General Information
The chemical compound calcium acetate is the calcium salt of acetic acid. An older name is acetate of lime. The anhydrous form is very hygroscopic, therefore the monohydrate is the common form. [Wikipedia]
Pharmacology of PhosLo
Patients with advanced renal insufficiency (creatinine clearance less than 30 ml/min) exhibit phosphate retention and some degree of hyperphosphatemia. The retention of phosphate plays a pivotal role in causing secondary hyperparathyroidism associated with osteodystrophy, and soft-tissue calcification. The mechanism by which phosphate retention leads to hyperparathyroidism is not clearly delineated. Therapeutic efforts directed toward the control of hyperphosphatemia include reduction in the dietary intake of phosphate, inhibition of absorption of phosphate in the intestine with phosphate binders, and removal of phosphate from the body by more efficient methods of dialysis. The rate of removal of phosphate by dietary manipulation or by dialysis is insufficient. Dialysis patients absorb 40% to 80% of dietary phosphorus. Therefore, the fraction of dietary phosphate absorbed from the diet needs to be reduced by using phosphate binders in most renal failure patients on maintenance dialysis. Calcium acetate when taken with meals combines with dietary phosphate to form insoluble calcium phosphate which is excreted in the feces. Maintenance of serum phosphorus below 6.0 mg/dl is generally considered as a clinically acceptable outcome of treatment with phosphate binders. Calcium acetate is highly soluble at neutral pH, making the calcium readily available for binding to phosphate in the proximal small intestine.
PhosLo for patients
PhosLo Interactions
Concomitant use with other calcium-containing medicines (including antacids) may cause too much calcium in the blood or urine, which may increase the chance of side effects. Using calcium acetate with digitalis glycosides (heart medicine) may cause hypercalcemia (too much calcium in the blood), which could increase the chance of developing an irregular heartbeat.
PhosLo Contraindications
Contraindicated in hypercalcemia (too much calcium in the blood) as calcium acetate may make this condition worse.
Additional information about PhosLo
PhosLo Indication: Used to treat hyperphosphatemia (too much phosphate in the blood) in patients with kidney disease. Mechanism Of Action: Calcium acetate works by binding with the phosphate in the food you eat, so that it is eliminated from the body without being absorbed. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Calcium Acetate Synonyms: Acetic acid, calcium salt; Brown acetate; Brown acetate of lime; Calcium acetate hydrate; Calcium acetate monohydrate; Calcium diacetate; Gray acetate; Gray acetate of lime; Grey acetate; Lime acetate; Lime pyrolignite; Procalamine; Pyrolignite of lime; Vinegar salts Drug Category: Antihyperphosphatemics; Chelating Agents Drug Type: Small Molecule; Approved Other Brand Names containing Calcium Acetate: Calac; Niacet calcium acetate tech; PhosLo; PhosLo Gelcaps; Sorbo-calcian; Sorbo-calcion; Teltozan; Absorption: 40% is absorbed in the fasting state and approximately 30% is absorbed in the nonfasting state following oral administration. Toxicity (Overdose): Oral, rat: LD50 = 4280 mg/kg. Symptoms of overdose include mild hypercalcemia (constipation; loss of appetite; nausea and vomiting), and severe hypercalcemia (confusion; full or partial loss of consciousness; incoherent speech). Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of PhosLo: Tablet OralLiquid OralSolution / drops Oral Chemical IUPAC Name: calcium diacetate Chemical Formula: C4H6CaO4 Calcium Acetate on Wikipedia: https://en.wikipedia.org/wiki/Calcium_Acetate Organisms Affected: Humans and other mammals