Pavulon

Pavulon - General Information

A bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent it is more potent than curare but has less effect on the circulatory system and on histamine release.

Pharmacology of Pavulon

Pavulon is a typical non-depolarising curare-mimetic muscle relaxant. It acts as a competitive acetylcholine antagonist on neuromuscular junctions, displacing acetylcholine (hence competitive) from its post-synaptic nicotinic acetylcholine receptors. It is, unlike suxamethonium, a non-depolarising agent, which means, that it causes no spontaneous depolarisations upon association with the nicotinic receptor in neuromuscular junction, thus producing no muscle fasciculations upon administration. Pavulon has no hormonal activity. It exerts slight vagolytic activity (i.e. diminishing activity of the vagus nerve) and no ganglioplegic (i.e., blocking ganglions) activity.

Additional information about Pavulon

Pavulon Indication: Used as a muscle relaxant during anesthesia and surgical procedures.
Mechanism Of Action: Nondepolarizing neuromuscular blocking agents inhibit neuromuscular transmission by competing with acetylcholine for the cholinergic receptors of the motor end plate, thereby reducing the response of the end plate to acetylcholine. This type of neuromuscular block is usually antagonized by anticholinesterase agents.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Pancuronium
Synonyms: Bromure de pancuronium [inn-french]; Bromuro de pancuronio [inn-spanish]; Pancuronium bromide; Pancuronium dibromide
Drug Category: Neuromuscular Nondepolarizing Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Pancuronium: Mioblock; Pavulon;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: 77 to 91%
Biotransformation: Hepatic.
Half Life: 1.5 to 2.7 hours.
Dosage Forms of Pavulon: Solution Intravenous
Liquid Intravenous
Chemical IUPAC Name: [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-3-acetyloxy-10,13-dimethyl-2,16-bis(1-methylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate dibromide
Chemical Formula: C35H60Br2N2O4
Pancuronium on Wikipedia: https://en.wikipedia.org/wiki/Pancuronium
Organisms Affected: Humans and other mammals