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Oxistat: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Oxistat - General Information

Oxistat nitrate (U.S.: Oxistat, Canada: Oxizole) is an antifungal medication typically administered in a cream or lotion to treat skin infections such as athlete's foot, jock itch and ringworm. [Wikipedia]

 

Pharmacology of Oxistat

Oxistat is a broad-spectrum imidazole derivative whose antifungal activity is derived primarily from the inhibition of ergosterol biosynthesis, which is critical for cellular membrane integrity. It has fungicidal or fungistatic activity in vitro against a number of pathogenic fungi including the following dermatophytes, and yeasts: T. rubrum, T. mentagrophytes, T. tonsurans, T. violaceum, E. floccosum, M. canis, M. audouini, M. gypseum, C. albicans, and M. furfur.

 

Oxistat for patients

The patient should be instructed to:

  1. Use OXISTAT as directed by the physician. The hands should be washed after applying the medication to the affected area(s). Avoid contact with the eyes, nose, mouth, and other mucous membranes. OXISTAT is for external use only.
  2. Use the medication for the full treatment time recommended by the physician, even though symptoms may have improved. Notify the physician if there is no improvement after 2 to 4 weeks, or sooner if the condition worsens.
  3. Inform the physician if the area of application shows signs of increased irritation, itching, burning, blistering, swelling, or oozing.
  4. Avoid the use of occlusive dressings unless otherwise directed by the physician.
  5. Do not use this medication for any disorder other than that for which it was prescribed.

 

Oxistat Interactions

Potential drug interactions between OXISTAT and other drugs have not been systematically evaluated.

 

Oxistat Contraindications

OXISTAT Cream and Lotion are contraindicated in individuals who have shown hypersensitivity to any of their components.

 

Additional information about Oxistat

Oxistat Indication: For treatment of dermal fungal infection. Mechanism Of Action: Oxistat inhibits ergosterol biosynthesis, which is required for cytoplasmic membrane integrity of fungi. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Oxiconazole Synonyms: Oxiconazole Nitrate; Oxiconazol [INN-Spanish]; Oxiconazolum [INN-Latin] Drug Category: Antifungal Agents Drug Type: Small Molecule; Approved Other Brand Names containing Oxiconazole: Oxistat; Absorption: Systemic absorption of oxiconazole is low. Toxicity (Overdose): Side effects incliude pruritus, burning, irritation, erythema, stinging and allergic contact dermatitis and folliculitis, fissuring, maceration rash and nodules. Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Oxistat: Cream TopicalLotion Topical Chemical IUPAC Name: 1-(2,4-dichlorophenyl)-N-[(2,4-dichlorophenyl)methoxy]-2-imidazol-1-ylethanimine Chemical Formula: C18H13Cl4N3O Oxiconazole on Wikipedia: https://en.wikipedia.org/wiki/Oxiconazole Organisms Affected: Fungi