Oxeze

Oxeze - General Information

Oxeze is a derivative of theophylline which shares bronchodilator properties. Oxeze is used in asthma, chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy. Long-term enprofylline administration may be associated with elevation in liver enzyme levels and unpredictable blood levels.

Pharmacology of Oxeze

Oxeze is a synthetic dimethylxanthine derivative structurally related to theophylline and caffeine. It antagonizes erythrocyte phosphodiesterase, increasing cAMP activity.

Additional information about Oxeze

Oxeze Indication: Used in the management of symptoms of asthma. Also used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy.
Mechanism Of Action: Oxeze inhibits erythrocyte phosphodiesterase, resulting in an increase in erythrocyte cAMP activity. Subsequently, the erythrocyte membrane becomes more resistant to deformity. Along with erythrocyte activity, enprofylline also decreases blood viscosity by reducing plasma fibrinogen concentrations and increasing fibrinolytic activity.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Enprofylline
Synonyms: 3-n-Propylxanthine; 3-Propylxanthine; Enprofilina [INN-Spanish]; Enprofyllinum [INN-Latin]
Drug Category: Anti-Asthmatic Agents; Antiarrhythmic Agents; Bronchodilator Agents; Anti-Inflammatory Agents, Non-Steroidal
Drug Type: Small Molecule; Approved

Other Brand Names containing Enprofylline: Nilyph; Oxeze;
Absorption: Rapidly absorbed from the digestive tract
Toxicity (Overdose): Not Available
Protein Binding: 49%
Biotransformation: Not Available
Half Life: 1.9 hours
Dosage Forms of Oxeze: Not Available
Chemical IUPAC Name: 3-propyl-7H-purine-2,6-dione
Chemical Formula: C8H10N4O2
Enprofylline on Wikipedia: Not Available
Organisms Affected: Humans and other mammals