Nuromax
Nuromax - General Information
Nuromax is a long-acting, nondepolarizing skeletal muscle relaxant for intravenous administration.
Pharmacology of Nuromax
Nuromax is a long-acting, nondepolarizing skeletal muscle relaxant. The neuromuscular block produced by doxacurium chloride may be antagonized by anticholinesterase agents. As with other nondepolarizing neuromuscular blocking agents, the more profound the neuromuscular block at reversal, the longer the time and the greater the dose of anticholinesterase required for recovery of neuromuscular function. Nuromax is approximately 2.5 to 3 times more potent than pancuronium and 10 to 12 times more potent than metocurine.
Nuromax for patients
Nuromax Interactions
Prior administration of succinylcholine has no clinically important effect on the neuromuscular blocking action of NUROMAX.
The use of NUROMAX before succinylcholine to attenuate some of the side effects of succinylcholine has not been studied.
There are no clinical data on concomitant use of NUROMAX and other nondepolarizing neuromuscular blocking agents.
Isoflurane, enflurane, and halothane decrease the ED50 of NUROMAX by 30% to 45%. These agents may also prolong the clinically effective duration of action by up to 25%.
Other drugs which may enhance the neuromuscular blocking action of nondepolarizing agents such as NUROMAX include certain antibiotics (e. g., aminoglycosides, tetracyclines, bacitracin, polymyxins, lincomycin, clindamycin, colistin, and sodium colistimethate), magnesium salts, lithium, local anesthetics, procainamide, and quinidine.
As with some other nondepolarizing neuromuscular blocking agents, the time of onset of neuromuscular block induced by NUROMAX is lengthened and the duration of block is shortened in patients receiving phenytoin or carbamazepine.
Nuromax Contraindications
NUROMAX is contraindicated in patients known to have hypersensitivity to it. Use of NUROMAX from multiple- dose vials containing benzyl alcohol as a preservative is contraindicated in patients with a known hypersensitivity to benzyl alcohol.
Additional information about Nuromax
Nuromax Indication: Used to provide skeletal muscle relaxation as an adjunct to general anesthesia, for endotracheal intubation or to facilitate mechanical ventilation.
Mechanism Of Action: Nuromax binds competitively to cholinergic receptors on the motor end-plate to antagonize the action of acetylcholine, resulting in a block of neuromuscular transmission. This action is antagonized by acetylcholinesterase inhibitors, such as neostigmine.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Doxacurium chloride
Synonyms: Not Available
Drug Category: Neuromuscular Nondepolarizing Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Doxacurium chloride: Nuromax;
Absorption: Not Available
Toxicity (Overdose): Overdosage with neuromuscular blocking agents may result in neuromuscular block beyond the time needed for surgery and anesthesia.
Protein Binding: Approximately 30%.
Biotransformation: In vivo data from humans suggest that doxacurium chloride is not metabolized and that the major elimination pathway is excretion of unchanged drug in urine and bile.
Half Life: 99 minutes in normal healthy adults.
Dosage Forms of Nuromax: Liquid Intravenous
Chemical IUPAC Name: bis[3-[6,7,8-trimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propyl] butanedioate dichloride
Chemical Formula: C56H78Cl2N2O16
Doxacurium chloride on Wikipedia: https://en.wikipedia.org/wiki/Doxacurium_chloride
Organisms Affected: Humans and other mammals