Medical Information Only: This medication is not sold on this site. The information provided is for reference purposes only. Please consult your local physician or pharmacist for treatment.

Novo-R: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Novo-R - General Information

An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novo-R binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189) [PubChem]

 

Pharmacology of Novo-R

Novo-R is an aminocoumarin antibiotic that was produced by the actinomycete Streptomyces niveus. Novo-R binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. Other antibiotics in the aminocoumarin class include coumermycin A1 and clorobiocin.

 

Additional information about Novo-R

Novo-R Indication: For the treatment of infections due to staphylococci and other susceptible organisms Mechanism Of Action: Novo-R is an aminocoumarin. Aminocoumarins are very potent inhibitors of bacterial DNA gyrase and work by targeting the GyrB subunit of the enzyme involved in energy tranduction. Novo-R as well as the other aminocoumarin antibiotics act as competitive inhibitors of the ATPase reaction catalysed by GyrB. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Novobiocin Synonyms: Novobiocina [Inn-Spanish]; Novobiocine [Inn-French]; Novobiocinum [Inn-Latin]; NOV; Crystallinic Acid; Antibiotic Pa-93 Drug Category: Anti-Bacterial Agents; Enzyme Inhibitors; Nucleic Acid Synthesis Inhibitors Drug Type: Small Molecule; Approved Other Brand Names containing Novobiocin: Albamix; Cardelmycin; Cathocin; Cathomycin; Inamycin; Novo-R; Robiocina; Sirbiocina; Spheromycin; Stilbiocina; Streptonivicin; Albamycin; Absorption: Oral bioavailability is negligible. Toxicity (Overdose): Not Available Protein Binding: 95% Biotransformation: Not Available Half Life: 6 hours Dosage Forms of Novo-R: Injection, powder, for solution Intravenous Chemical IUPAC Name: [(3R,4S,5R,6R)-5-hydroxy-6-[2-hydroxy-3-[[4-hydroxy-3-(3-methylbut-2-enyl)benzoyl]amino]-8-methyl-4-oxochromen-7-yl]oxy-3-methoxy-2,2-dimethyloxan-4-yl] carbamate Chemical Formula: C31H36N2O11 Novobiocin on Wikipedia: https://en.wikipedia.org/wiki/Novobiocin Organisms Affected: Enteric bacteria and other eubacteria