Novo-Cloxin
Novo-Cloxin - General Information
A semi-synthetic antibiotic that is a chlorinated derivative of oxacillin. [PubChem]
Pharmacology of Novo-Cloxin
Novo-Cloxin is a semisynthetic antibiotic in the same class as penicillin. Novo-Cloxin is for use against staphylococci that produce beta-lactamase.
Additional information about Novo-Cloxin
Novo-Cloxin Indication: Used to treat infections caused by penicillinase-producing staphylococci, including pneumococci, group A beta-hemolytic streptococci, and penicillin G-sensitive and penicillin G-resistant staphylococci.
Mechanism Of Action: By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, cloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cloxacillin interferes with an autolysin inhibitor.
Drug Interactions: Methotrexate The penicillin increases the effect and toxicity of methotrexate
Anisindione The IV penicillin increases the anticoagulant effect
Dicumarol The IV penicillin increases the anticoagulant effect
Acenocoumarol The IV penicillin increases the anticoagulant effect
Warfarin The IV penicillin increases the anticoagulant effect
Demeclocycline Possible antagonism of action
Doxycycline Possible antagonism of action
Ethinyl Estradiol This anti-infectious agent could decrease the effect of the oral contraceptive
Mestranol This anti-infectious agent could decrease the effect of the oral contraceptive
Methacycline Possible antagonism of action
Minocycline Possible antagonism of action
Oxytetracycline Possible antagonism of action
Rolitetracycline Possible antagonism of action
Tetracycline Possible antagonism of action
Food Interactions: Take on an empty stomach.
Generic Name: Cloxacillin
Synonyms: Cloxacillin Sodium
Drug Category: Anti-Bacterial Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Cloxacillin: Novo-Cloxin; Nu-Cloxi;
Absorption: Well absorbed from the gastrointestinal tract.
Toxicity (Overdose): Oral LD50 in rat and mouse is 5000 mg/kg. Intravenous LD50 in rat is 1660 mg/kg. Symptoms of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, and swelling of face, lips, tongue, or throat.
Protein Binding: 95%
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Novo-Cloxin: Powder, for solution Intramuscular
Powder, for solution Oral
Powder, for solution Intravenous
Capsule Oral
Chemical IUPAC Name: (2S,5R,6R)-6-[[3-(2-chlorophenyl)-5-methyl1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Chemical Formula: C19H18ClN3O5S
Cloxacillin on Wikipedia: https://en.wikipedia.org/wiki/Cloxacillin
Organisms Affected: Enteric bacteria and other eubacteria
