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Noroxin: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Noroxin - General Information

A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Noroxin inhibits bacterial DNA gyrase. [PubChem]

 

Pharmacology of Noroxin

Noroxin is a quinolone/fluoroquinolone antibiotic. Noroxin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian.

 

Noroxin for patients

 

Noroxin Interactions

Elevated plasma levels of theophylline have been reported with concomitant quinolone use. There have been reports of theophylline-related side effects in patients on concomitant therapy with norfloxacin and theophylline. Therefore, monitoring of theophylline plasma levels should be considered and dosage of theophylline adjusted as required.

Elevated serum levels of cyclosporine have been reported with concomitant use of cyclosporine with norfloxacin. Therefore, cyclosporine serum levels should be monitored and appropriate cyclosporine dosage adjustments made when these drugs are used concomitantly.

Quinolones, including norfloxacin, may enhance the effects of oral anticoagulants, including warfarin or its derivatives or similar agents. When these products are administered concomitantly, prothrombin time or other suitable coagulation tests should be closely monitored.

The concomitant administration of quinolones including norfloxacin with glyburide (a sulfonylurea agent) has, on rare occasions, resulted in severe hypoglycemia. Therefore, monitoring of blood glucose is recommended when these agents are co-administered.

Diminished urinary excretion of norfloxacin has been reported during the concomitant administration of probenecid and norfloxacin.

The concomitant use of nitrofurantoin is not recommended since nitrofurantoin may antagonize the antibacterial effect of Norfloxacin in the urinary tract.

Multivitamins, or other products containing iron or zinc, antacids or sucralfate should not be administered concomitantly with, or within 2 hours of, the administration of norfloxacin, because they may interfere with absorption resulting in lower serum and urine levels of norfloxacin.

Videx (Didanosine) chewable/buffered tablets or the pediatric powder for oral solution should not be administered concomitantly with, or within 2 hours of, the administration of norfloxacin, because these products may interfere with absorption resulting in lower serum and urine levels of norfloxacin.

Some quinolones have also been shown to interfere with the metabolism of caffeine. This may lead to reduced clearance of caffeine and a prolongation of its plasma half-life.

 

Noroxin Contraindications

Norfloxacin is contraindicated in persons with a history of hypersensitivity, tendinitis, or tendon rupture associated with the use of norfloxacin or any member of the quinolone group of antimicrobial agents.

 

Additional information about Noroxin

Noroxin Indication: For the treatment of urinary tract infection Mechanism Of Action: The bactericidal action of Noroxin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination. Noroxin is a broad-spectrum antibiotic that is active against both gram-positive and gram-negative bacterias. The fluorine atom at the 6 position increases potency against gram-negative organisms, and the piperazine moiety at the 7 position is responsible for anti-pseudomonal activity Drug Interactions: Aluminium Formation of non-absorbable complexesBismuth Formation of non-absorbable complexesCalcium Formation of non-absorbable complexesMagnesium oxide Formation of non-absorbable complexesMagnesium Formation of non-absorbable complexesIron Formation of non-absorbable complexesZinc Formation of non-absorbable complexesSucralfate Formation of non-absorbable complexesTheophylline The quinolone increases the effect of theophyllineOxtriphylline The quinolone increases the effect of theophyllineAminophylline The quinolone increases the effect of theophyllineDyphylline The quinolone increases the effect of theophyllineAnisindione The quinolone increases the anticoagulant effectAcenocoumarol The quinolone increases the anticoagulant effectDicumarol The quinolone increases the anticoagulant effectWarfarin The quinolone increases the anticoagulant effectCaffeine The quinolone increases the effect and toxicity of caffeineCyclosporine The quinolone increases the effect and toxicity of cyclosporineClozapine Ciprofloxacin may increase clozapine serum levelsFoscarnet Increased risk of convulsions Food Interactions: Not Available Generic Name: Norfloxacin Synonyms: Not Available Drug Category: Anti-Infectives; Enzyme Inhibitors; Quinolones Drug Type: Small Molecule; Approved Other Brand Names containing Norfloxacin: Chibroxin; Noroxin; Absorption: Rapid Toxicity (Overdose): Not Available Protein Binding: 10 and 15% (Serum protein binding) Biotransformation: Via liver and kidney Half Life: 3-4 hours Dosage Forms of Noroxin: Tablet Oral Chemical IUPAC Name: 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid Chemical Formula: C16H18FN3O3 Norfloxacin on Wikipedia: https://en.wikipedia.org/wiki/Norfloxacin Organisms Affected: Enteric bacteria and other eubacteria