Nilodin

Nilodin - General Information

One of the schistosomicides, it has been replaced largely by hycanthone and more recently praziquantel. (From Martindale The Extrapharmacopoeia, 30th ed., p46). It is currently being tested as a radiation sensitizer.

Pharmacology of Nilodin

Although lucanthone has structural and biochemical similarities to Actinomycin D, it has no hematological or gastro-intestinal toxicity at clinically tolerated doses. In trials, Nilodin was found to be safe, practical and effective and was proposed for use in clinical protocols for the treatment of cancer. The specificity of lucanthone in combination with radiation for the treatment of brain tumors arises from the fact that lucanthone acts preferentially on cycling cells (most of the normal brain cells are non-cycling) and the fact that lucanthone crosses the blood brain barrier efficiently.

Additional information about Nilodin

Nilodin Indication: Intended for use as a radiation sensitizer in the treatment of brain cancer.
Mechanism Of Action: Recent data suggests that lucanthone inhibits post-radiation DNA repair in tumor cells. The ability of lucanthone to inhibit AP endonuclease and topoisomerase II probably account for the specific DNA repair inhibition in irradiated cells.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Lucanthone
Synonyms: Lucantona [inn-spanish]; Lucanthonum [inn-latin]; Lucanthone monohydrochloride; Lucanthone hydrochloride; Lucanthon; 1-[[2-(Diethylamino)ethyl]amino]-4-methylthioxanthone; 1-((2-(Diethylamino)ethyl)amino)-4-methylthioxanthen-9-one
Drug Category: Radiation-Sensitizing Agents; Schistosomicides; Anticancer Agents
Drug Type: Small Molecule; Approved; Investigational

Other Brand Names containing Lucanthone: Nilodin; Miracil D; Scapuren; Tixantone; Miracol;
Absorption: Orally available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Nilodin: Not Available
Chemical IUPAC Name: 1-(2-diethylaminoethylamino)-4-methylthioxanthen-9-one
Chemical Formula: C20H24N2OS
Lucanthone on Wikipedia: Not Available
Organisms Affected: Humans and other mammals