Naftin
Naftin - General Information
Naftin is a synthetic, broad spectrum, antifungal agent and allylamine derivative for the topical treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organisms Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans and Epidermophyton floccosum.
Pharmacology of Naftin
Naftin is a synthetic, broad spectrum, antifungal agent and allylamine derivative. The following in vitro data are available, but their clinical significance is unknown. Naftin has been shown to exhibit fungicidal activity in vitro against a broad spectrum of organisms including Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Epidermophyton floccosum, and Microsporum canis, Microsporum audouini, and Microsporum gypseum; and fungistatic activity against Candida species including Candida albicans. However it is only used to treat the organisms listed in the indications.
Naftin for patients
The patient should be told to:
- Avoid the use of occlusive dressings or wrappings unless otherwise directed by the physician.
- Keep NAFTIN Gel 1% away from the eyes, nose, mouth and other mucous membranes.
Naftin Interactions
No information provided.
Naftin Contraindications
NAFTIN Gel 1% is contraindicated in individuals who have shown hypersensitivity to any of its components.
Additional information about Naftin
Naftin Indication: For the topical treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organisms Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans and Epidermophyton floccosum.
Mechanism Of Action: Although the exact mechanism of action against fungi is not known, naftifine appears to interfere with sterol biosynthesis by inhibiting the enzyme squalene 2,3-epoxidase. This inhibition of enzyme activity results in decreased amounts of sterols, especially ergosterol, and a corresponding accumulation of squalene in the cells.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Naftifine
Synonyms: Not Available
Drug Category: Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Naftifine: Naftifine HCl; Naftin;
Absorption: Following single topical applications of 3H-labeled naftifine gel 1% to the skin of healthy subjects, up to 4.2% of the applied dose was absorbed.
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Approximately 2 to 3 days following topical administration.
Dosage Forms of Naftin: Gel Topical
Cream Topical
Chemical IUPAC Name: N-methyl-N-(naphthalen-1-ylmethyl)-3-phenylprop-2-en-1-amine
Chemical Formula: C21H21N
Naftifine on Wikipedia: https://en.wikipedia.org/wiki/Naftifine
Organisms Affected: Yeast and other fungi
