Nadide
Nadide - General Information
Nadide is the reduced form of NAD+, and NAD+ is the oxidized form of Nadide, A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (Nadide). It forms NADP with the addition of a phosphate group to the 2' position of the adenosyl nucleotide through an ester linkage.(Dorland, 27th ed)
Pharmacology of Nadide
A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (Nadide). The action of supplemental Nadide is unclear. Oral Nadide supplementation has been used to combat simple fatigue as well as such mysterious and energy-sapping disorders as chronic fatigue syndrome and fibromyalgia. Researchers are also studying the value of Nadide supplements for improving mental function in people with Alzheimer's disease, and minimizing physical disability and relieving depression in people with Parkinson's disease. Some healthy individuals also take Nadide supplements orally to improve concentration and memory capacity, as well as to increase athletic endurance. However, to date there have been no published studies to indicate that using Nadide is in any way effective or safe for these purposes.
Nadide for patients
Nadide Interactions
Nadide Contraindications
None known.
Additional information about Nadide
Nadide Indication: Some evidence suggests that Nadide might be useful in treating Parkinson's disease, chronic fatigue syndrome, Alzheimer's disease and cardiovascular disease.
Mechanism Of Action: Nadide is synthesized by the body and thus is not an essential nutrient. It does require the essential nutrient nicotinamide for its synthesis, and its role in energy production is certainly an essential one. In addition to its role in the mitochondrial electron transport chain, Nadide is produced in the cytosol. The mitochondrial membrane is impermeable to Nadide, and this permeability barrier effectively separates the cytoplasmic from the mitochondrial Nadide pools. However, cytoplasmic Nadide can be used for biologic energy production. This occurs when the malate-aspartate shuttle introduces reducing equivalents from Nadide in the cytosol to the electron transport chain of the mitochondria. This shuttle mainly occurs in the liver and heart.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: NADH
Synonyms: beta-DPNH; beta-NADH; Coenzyme I, reduced; Cozymase I, reduced; dihydrodiphosphopyridine nucleotide; dihydronicotinamide adenine dinucleotide; Diphosphopyridine nucleotide; diphosphopyridine nucleotide reduced; DPN; DPNH; NAD+; NAD-reduced; NADH+H+; NADH2; Nicotinamide adenine dinucleotide; nicotinamide adenine dinucleotide reduced; Nicotinaminde-Adenine-Dinucleotide; DPN+
Drug Category: Dietary supplement; Micronutrient
Drug Type: Small Molecule; Nutraceutical; Approved
Other Brand Names containing NADH: Nadide;
Absorption: Unclear how much of an administered dose is absorbed.
Toxicity (Overdose): No reports of overdose, however, high doses of NADH (10 mg a day or more) may cause jitteriness, anxiety, and insomnia.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Nadide: Tablet Oral
Chemical IUPAC Name: [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [[(2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] hydrogen phosphate
Chemical Formula: C21H29N7O14P2
NADH on Wikipedia: https://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide
Organisms Affected: Humans and other mammals