Moban

Moban - General Information

An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Moban has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of clozapine. (From AMA Drug Evaluations Annual, 1994, p283)

Pharmacology of Moban

Moban is a dihydroindolone compound which is not structurally related to the phenothiazines, the butyrophenones or the thioxanthenes. Moban has a pharmacological profile in laboratory animals which predominantly resembles that of major tranquilizers causing reduction of spontaneous locomotion and aggressiveness, suppression of a conditioned response and antagonism of the bizarre stereotyped behavior and hyperactivity induced by amphetamines. In addition, molindone antagonizes the depression caused by the tranquilizing agent tetrabenazine.

Moban for patients

Moban Interactions

Moban Contraindications

MOBAN is contraindicated in severe central nervous system depression (alcohol, barbiturates, narcotics, etc.) or comatose states, and in patients with known hypersensitivity to the drug.

Additional information about Moban

Moban Indication: For the management of the manifestations of psychotic disorders.
Mechanism Of Action: The exact mechanism has not been established, however, based on electroencephalogram (EEG) studies, molindone is thought to act by occupying dopamine (D2) receptor sites in the reticular activating and limbic systems in the brain, thus decreasing dopamine activity.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Molindone
Synonyms: (+-)-molindone; Molindona [inn-spanish]; Molindonum [inn-latin]
Drug Category: Antipsychotic Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Molindone: Moban;
Absorption: Rapidly absorbed from the gastrointestinal tract following oral administration.
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Most likely hepatic. 36 metabolites have been recognized, some of which may be active.
Half Life: Not Available
Dosage Forms of Moban: Tablet Oral
Chemical IUPAC Name: 3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one
Chemical Formula: C16H24N2O2
Molindone on Wikipedia: https://en.wikipedia.org/wiki/Molindone
Organisms Affected: Humans and other mammals