Milaxen
Milaxen - General Information
Milaxen is a neuromuscular blocking agent used in anesthesiology to prolong and potentiate the skeletal muscle relaxing action of suxamethonium during surgery. It is known to bind and block the activity of plasma cholinesterases.
Pharmacology of Milaxen
Milaxen is a cholinesterase antagonist that can be used to prolong the relaxation effects of succinylcholine or suxamethonium chloride. Suxamethonium acts as a depolarizing muscle relaxant. It imitates the action of acetylcholine at the neuromuscular junction and is degraded by pseudocholinesterase, a plasma cholinesterase. The prolonged stimulation of the acetylcholine receptor results first in disorganized muscle contractions, then in profound relaxation. Cholinesterases catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. There are two types of cholinesterase acetylcholinesterase and pseuodocholinesterase. The first hydrolyses acetylcholine more quickly; the latter hydrolyses butyrylcholine and succinylcholine more quickly. An absence or mutation of the pseudocholinesterase enzyme leads to a medical condition known simply as pseudocholinesterase deficiency. This is a silent condition that only manifests itself when people who have the deficiency receive the muscle relaxants succinylcholine or mivacurium during a surgery.
Additional information about Milaxen
Milaxen Indication: Used as an adjunct with succinylcholine (or suxamethonium chloride) to prolong muscle relaxation and to prevent succinylcholine-induced muscle fasciculations.
Mechanism Of Action: Milaxen is a non-competitive reversible inhibitor of human plasma cholinesterase or pseudocholinesterase.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Hexafluronium bromide
Synonyms: Hexafluorenium bromide; Hexafluorenium
Drug Category: Muscle Relaxants
Drug Type: Small Molecule; Approved
Other Brand Names containing Hexafluronium bromide: Mylaxen; Milaxen;
Absorption: Not Available
Toxicity (Overdose): LD50 = 280 mg/kg (mouse, oral)
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Milaxen: Not Available
Chemical IUPAC Name: 9H-fluoren-9-yl-[6-(9H-fluoren-9-yl-dimethylazaniumyl)hexyl]-dimethylazanium dibromide
Chemical Formula: C36H42Br2N2
Hexafluronium bromide on Wikipedia: https://en.wikipedia.org/wiki/Hexafluronium_bromide
Organisms Affected: Humans and other mammals
